Results 151 to 160 of about 804,926 (346)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
The Impact of Accretion on FRB Radiation Mechanisms in Binary Systems: Constraints and Implications
The Astrophysical JournalFast radio bursts (FRBs) are intense, millisecond-duration radio transients that have recently been proposed to arise from coherent radiation mechanisms within the magnetosphere of neutron stars.
Gong-Yu Yao, Can-Min Deng
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
The Astrophysical JournalConstrained measurements of fundamental physical constants using astronomical observational data represent a powerful method for investigating potential new physics. In particular, the dispersion measure (DM) of fast radio bursts (FRBs), which probes the
Shi-Yuan Wang, Jun-Qing Xia
doaj +1 more source
Transient Electromagnetic Field Characteristics of A New Source-Conical Source [PDF]
, 2016 Haiyan Yang, Fengping Li
openalex +1 more source
Impact of the transient stability constraint on unit commitment with renewable energy sources
, 2022 Shriram Shukla
openalex +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Can Repeating and Nonrepeating Fast Radio Bursts Be Drawn from the Same Population?
The Astrophysical JournalDo all fast radio burst (FRB) sources repeat? We present evidence that FRB sources follow a Zipf-like distribution, in which the number density of sources is approximately inversely proportional to their burst rate above a fixed energy threshold—even ...
Paz Beniamini, Pawan Kumar
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
A Unified Volumetric Rate–Energy Relation from Magnetar Radio Bursts to Fast Radio Bursts
The Astrophysical JournalFast radio bursts (FRBs) are millisecond radio pulses with extremely high bright temperature. Their physical origin is still a mystery. The discovery of FRB 20020428 supports the idea that at least a portion of FRBs is generated by magnetars.
Hao-Tian Lan, Shuang-Xi Yi, Fa-Yin Wang
doaj +1 more source