Results 111 to 120 of about 451,642 (327)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Modeling of virtual synchronous controlled-DFIG considering stator voltage control dynamics for transient stability analysis

International Journal of Electrical Power & Energy Systems
Transient stability of virtual synchronous controlled (VSynC) equipment is usually analyzed without considering the dynamics of the AC voltage controller.
Xiangkun Meng, Shiying Ma, Chao Zheng
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Power Transmission Limits Assessment on PCC of Grid-connected Wind Power Based on Nodal Electromagnetic Transient Thevenin Equivalence

Taiyuan Ligong Daxue xuebao
Purposes Transmission power limit exists in point of common coupling (PCC) of grid-connected wind power, when the transmission power exceeds the limit, it may lead to voltage instability and broadband oscillation problems, threatening the safety and ...
GUO Xiaolong, KANG Pengpeng, SONG Pengfei, CHEN Wuhui, KANG Jiale   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dynamic Reactive Power Allocation Method of Power Grid with High-Permeability PV Considering Transient Voltage Stability

Energies
In order to solve the risk of transient voltage instability caused by the increasing proportion of new energy represented by photovoltaic (PV) and dynamic load in the power grid, a dynamic reactive power compensation device configuration method with high-
Yangyang Li, Dongfeng Yang, Chuang Liu, Dongbo Guo, Yichen Gu, Jiahe Li   +5 more
doaj   +1 more source

Quasi-digital low-dropout voltage regulators uses controlled pass transistors [PDF]

, 2016
This article presents a low quiescent current output capacitorless quasi-digital CMOS LDO regulator with controlled pass transistors according to load demands.
Alarcón Cot, Eduardo José, Martínez García, Herminio, Saberkari, Alireza   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Optimal Determination of Synchronous Condenser Placement and Voltage Setting for Enhancing Power System Stability

Energies
With the increasing share of renewable energy in power systems, the instability of the power systems is becoming increasingly significant. Consequently, power system stability has become a critical issue, and non-transmission alternatives have been ...
Juseong Lee, Hyeongjun Jo, Soobae Kim
doaj   +1 more source