Results 191 to 200 of about 273,606 (300)

VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation. [PDF]

Sci Adv
Sulaman BA, Chen E, Crane A, Lee S, Rothschild G, Eban-Rothschild A.   +5 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Orai storeoperated Ca²⁺ entry channels modulate urethral smooth muscle contractility. [PDF]

Channels (Austin)
Drumm BT, Gupta N.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Temperature Dependence of the Vibrational Wave-Packet Dynamics of Cu₅. [PDF]

J Phys Chem A
Han J, Bastian B, Jorewitz M, Asmis KR, Jin J.   +4 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Nodal Na⁺ and Ca²⁺ flux dynamics in cortical myelinated axons. [PDF]

Front Cell Neurosci
Kotler O, Miyazaki K, Khrapunsky Y, Ross WN, Fleidervish IA.   +4 more
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

StarWhisper Telescope: an AI framework for automating end-to-end astronomical observations. [PDF]

Commun Eng
Wang C, Zhang Y, Li Y, Hu X, Mao Y, Chen X, Du P, Wang R, Wu Y, Yang H, Li Y, Wang B, Mu H, Chen X, He S, Mo H, Zhang L, Du L, Zhao Y, Tian J, Ge L, Mao Y, Li S, Wang Z, Lu X, Zou J, Huang Y, Sun N, Zheng J, He M, Bai Y, Jin J, Wu H, Liu J.   +33 more
europepmc   +1 more source