Results 71 to 80 of about 5,368 (307)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Professional migrants in Cape Town : identity, culture and community
, 2008 Before the 1990's, African migrants did not perceive South Africa as an ideal migration destination. This changed after the end of the apartheid era.
Shea, Lenri
core
Ecology and behaviour of winter floaters in a subalpine population of Willow Tits, Poecile montanus
, 2013 Willow Tits Poecile montanus maintain yearlong territories defended by a male and fe-male mated pair. Outside the breeding season the adult pair lives together with two to four unrelated first-year Willow Tits that have settled after a post-natal ...
Olav Hogstad, Hogstad, Olav
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Preventive Medicine ReportsObjectives: To evaluate the association between the perception of discrimination by the head of the household and the presence of moderate to severe food insecurity in the households of Venezuelan migrants and refugees residing in Peru.
Darlene Milagros Rocha-Rojas +3 more
doaj +1 more source
‘A Class Apart’?: South Asian Immigrants and the White Working Class Left, Yorkshire 1960-1981 [PDF]
, 2011 During the 1960s many thousands of South Asian immigrants arrived in the United Kingdom. At first they were, by and large, economic migrants looking to fill British labour shortages and send remittances back home.
Swift, David
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source