Results 151 to 160 of about 131,449 (311)

Smart CaCO₃-coated probiotics relieve constipation by enhancing intestinal motility and modulating microbial enzymes in a loperamide-induced rat model. [PDF]

Sci Rep
Jeong SN, Kim MJ.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Effect of containment strategies for respiratory diseases on infections imported via international travel to the USA: a modelling study. [PDF]

BMJ Open
Koiso S, Lee H, Ciaranello AL, Freedberg KA, Ryan ET, Jalali MS, LaRocque RC, Hyle EP.   +7 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Seven-year data trends in mental health of refugees in transit: a repeated cross-sectional study. [PDF]

Lancet Reg Health Eur
Vukčević Marković M, Šapić D, Živić I, Stanković I, Bobić A, Stojadinović Vujičić I, Dimoski J.   +6 more
europepmc   +1 more source

Mean Direct-Transit and Looping Times as Functions of the Potential Shape.

Journal of Physical Chemistry B, 2017
A. Berezhkovskii, L. Dagdug, S. Bezrukov
semanticscholar   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Unlocking the colon clock: Bridging the gap in colonic transit time studies for optimal management of chronic constipation. [PDF]

World J Gastrointest Pharmacol Ther
Kalra S, Goyal MK, Goyal K, Singh R, Vuthaluru AR, Goyal O.   +5 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Travel microbiota: a novel frontier in travel medicine exploring microbial shifts across transportation modes. [PDF]

Trop Dis Travel Med Vaccines
Tiwary P, Oswal K, Tzvetkov NT, Litvinova O, Atanasov AG, Varghese R.   +5 more
europepmc   +1 more source