Results 121 to 130 of about 76,246 (270)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The Astrophysical Journal Supplement SeriesDiscovering and characterizing exoplanets at the outer edge of the transit method’s sensitivity has proven challenging owing to geometric biases and the practical difficulties associated with acquiring long observational baselines.
Paul A. Dalba +31 more
doaj +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Investigating the Atmospheric Mass Loss of the Kepler-105 Planets Straddling the Radius Gap
The Astronomical JournalAn intriguing pattern among exoplanets is the lack of detected planets between approximately 1.5 R _⊕ and 2.0 R _⊕ . One proposed explanation for this “radius gap” is the photoevaporation of planetary atmospheres, a theory that can be tested by studying ...
Aaron Householder +23 more
doaj +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
The Astronomical JournalTOI-1266 is a benchmark system of two temperate (
Michael Greklek-McKeon +40 more
doaj +1 more source
Fast Inversion Method for Determination of Planetary Parameters from Transit Timing Variations
, 2009 David Nesvorný, C. Beaugé
openalex +1 more source
FEBS Open Bio, EarlyView.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source
A Compact Multiplanet System of Three Transiting Giant Planets around TIC 118798035
The Astrophysical Journal LettersWe report the discovery and characterization of three transiting giant planets in the TIC 118798035 system. The three planets were identified as transiting candidates from data of the TESS mission and confirmed with ground-based photometric transit ...
Rafael Brahm +22 more
doaj +1 more source
Real-time Evaluation Model for Metro Station Passenger Flow Streamline Congestion State
Chengshi guidao jiaotong yanjiu[Objective] Implementing precise initiation, performance evaluation and dynamic information dissemination of metro station large passenger flow management and control measures requires more effective support.
SHI Pingcui +4 more
doaj +1 more source