Results 41 to 50 of about 1,838,465 (255)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Changement climatique : quelle stratégie d'adaptation pour les territoires de montagne? Préface [PDF]

Sciences, Eaux & Territoires, 2019
Préface
EBNER, Pascale, EBNER, Pascale
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Points de vue - La stratégie française pour relever le défi de la mise en œuvre des outils de la directive cadre européenne sur l’eau [PDF]

Sciences, Eaux & Territoires, 2021
La directive cadre européenne sur l’eau (DCE) a donné une impulsion forte à la politique française menée en matière de bio-indication. Le bon état écologique des masses d’eau est devenu l’un des indicateurs majeurs de pilotage et d’évaluation de la ...
SPYRATOS, Vassilis, SPYRATOS, Vassilis
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

In need of a sustainable and just fashion industry: identifying challenges and opportunities through a systematic literature review in a Global North/Global South perspective

Discover Sustainability
Since the late twentieth century, the global fashion industry has been increasingly embracing the business model known as fast fashion. Characterised by rapid production cycles, fleeting trends, low-cost garments and large-scale production, fast fashion ...
Francesca Bonelli, Rocco Caferra, Piergiuseppe Morone   +2 more
doaj   +1 more source

Wildfire Impacts on Security of Electric Power Systems: A Survey of Risk Identification and Mitigation Approaches

IEEE Access
The increase of extremely hot days globally has led to more frequent wildfires and frequent power outages directly and indirectly caused by the wildfires.
Rakibuzzaman Shah, Nima Amjady, Nusrat Subah Binte Shakhawat, Muhammad Usman Aslam, MD. Sazal Miah   +4 more
doaj   +1 more source

Toots, tastes and tester shots: user accounts of drug sampling methods for gauging heroin potency

Harm Reduction Journal, 2018
Background Internationally, overdose is the primary cause of death among people injecting drugs. However, since 2001, heroin-related overdose deaths in the United States (US) have risen sixfold, paralleled by a rise in the death rate attributed to ...
Sarah G. Mars, Jeff Ondocsin, Daniel Ciccarone   +2 more
doaj   +1 more source