Results 91 to 100 of about 451,806 (340)

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Genetic regulation of life cycle transitions in the brown alga Ectocarpus [PDF]

Plant Signaling & Behavior, 2011
The life cycle of an organism is one of its most elemental features, underpinning a broad range of phenomena including developmental processes, reproductive fitness, mode of dispersal and adaptation to the local environment. Life cycle modification may have played an important role during the evolution of several eukaryotic groups, including the ...
Coelho, Susana M., Godfroy, Olivier, Arun, Alok, Le Corguillé, Gildas, Peters, Akira.F., Mark Cock, J.   +5 more
openaire   +3 more sources

Error threshold in the evolution of diploid organisms

, 1996
The effects of error propagation in the reproduction of diploid organisms are studied within the populational genetics framework of the quasispecies model. The dependence of the error threshold on the dominance parameter is fully investigated.
D Alves, Eigen M, Eigen M, Eigen M, Franz S, Galluccio S, Hartl D L, J F Fontanari, Kauffman S A, Leuthäusser I   +9 more
core   +1 more source

Tractable diffusion and coalescent processes for weakly correlated loci [PDF]

, 2015
Widely used models in genetics include the Wright-Fisher diffusion and its moment dual, Kingman's coalescent. Each has a multilocus extension but under neither extension is the sampling distribution available in closed-form, and their computation is ...
Fearnhead, Paul, Jenkins, Paul A., Song, Yun S.   +2 more
core   +3 more sources

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

IT Complexity Revolution: Intelligent Tools for the Globalised World Development

, 2009
Globalised-civilisation interaction intensity grows exponentially, involving all dimensions and regions of planetary environment. The resulting dynamics of critically high, exploding complexity urgently needs consistent understanding and efficient ...
Kirilyuk, Andrei, Ulieru, Mihaela
core   +4 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Temporal profiles describing markers of inflammation and metabolism during the transition period of pasture-based, seasonal-calving dairy cows

Journal of Dairy Science, 2022
: The physiology of the dairy cow while transitioning from pregnancy to lactation is complex, with multifactorial processes studied extensively for the role they play in manifestation of disease along with associated economic losses and compromised ...
O.K. Spaans, B. Kuhn-Sherlock, A. Hickey, M.A. Crookenden, A. Heiser, C.R. Burke, C.V.C. Phyn, J.R. Roche   +7 more
doaj  

A novel spectral method for inferring general diploid selection from time series genetic data

, 2014
The increased availability of time series genetic variation data from experimental evolution studies and ancient DNA samples has created new opportunities to identify genomic regions under selective pressure and to estimate their associated fitness ...
Bhaskar, Anand, Song, Yun S., Steinrücken, Matthias   +2 more
core   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source