Results 31 to 40 of about 172,050 (245)
Currently Clinical Views on Genetics of Wilson′s Disease
Chinese Medical Journal, 2015 Objective: The objective of this study was to review the research on clinical genetics of Wilson′s disease (WD). Data Sources: We searched documents from PubMed and Wanfang databases both in English and Chinese up to 2014 using the keywords WD in ...
Chen Chen +5 more
doaj +1 more source
The (r)evolution of cancer genetics
BMC Biology, 2010 The identification of an increasing number of cancer genes is opening up unexpected scenarios in cancer genetics. When analyzed for their systemic properties, these genes show a general fragility towards perturbation.
Ciccarelli Francesca D
doaj +1 more source
The formation of cancer stem cells in EMT6/Ro tumor: Hybrid modeling within its micro-environment
Informatics in Medicine Unlocked, 2020 We investigate the formation of cancer stem cells and their role in maintaining avascular solid tumors. For this purpose, we provide a mathematical framework to study the major biological interpretations on the stemness of cancerous cells (stochastic ...
Armin Pirastehzad +2 more
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Frontiers in Oncology, 2021 Lung cancer is the leading cause of cancer-related deaths and is the primary source of brain metastases. Despite great advances in the study of the genetics and etiology of lung cancer in previous decades, the identification of the factors and mechanisms
Xu-Ge Wei, Ke-Wei Bi, Bo Li
doaj +1 more source
Genetic visualization of protein interactions harnessing liquid phase transitions [PDF]
Scientific Reports, 2017 AbstractProtein-protein interactions (PPIs) are essential components of cellular function. Current fluorescence-based technologies to measure PPIs have limited dynamic range and quantitative reproducibility. Here, we describe a genetically-encoded PPI visualization system that harnesses the dynamics of condensed liquid-phase transitions to analyze ...
Taku Watanabe +9 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Characterizing stressful events reported by childhood cancer survivors experienced throughout the lifespan may help improve trauma‐informed care relevant to the survivor experience. Methods Participants included 2552 survivors (54% female; 34 years of age) and 469 community controls (62% female; 33 years of age) from the St.
Megan E. Ware +13 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.Abstract Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy affecting millions of individuals worldwide. The clinical expression and psychosocial burden of SCD vary widely across geographical, cultural, and healthcare system contexts, underscoring the need for setting‐specific approaches to assessment.
Desiré Fantasia +7 more
wiley +1 more source
From rat pathophysiology to genomic medicine: an interview with Howard Jacob
Disease Models & Mechanisms, 2016 Howard Jacob is best known for pioneering genomic sequencing of a patient to solve a mysterious pediatric case in 2010. With roots in pharmacology and cardiovascular disease, however, his career has largely been dedicated to dissecting the physiology and
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning
Journal of Developmental Biology, 2018 EGF, emitted by the Anchor Cell, patterns six equipotent C. elegans vulval precursor cells to assume a precise array of three cell fates with high fidelity.
Hanna Shin, David J. Reiner
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