Results 81 to 90 of about 480,980 (318)
Clinical genetics in transition—a comparison of genetic services in Estonia, Finland, and the Netherlands [PDF]
, 2021 Terry Vrijenhoek +4 more
openalex +1 more source
New England Genetics Collaborative Results of the Stakeholder Survey for Project Year Four [PDF]
, 2012 Stakeholder feedback offers a range of critical and helpful insights into the potential next steps for the collaborative as it carriers on activities for Project Year Five and plans for a new grant application.
Antal, Peter
core +1 more source
Adaptation in tunably rugged fitness landscapes: The Rough Mount Fuji Model
, 2014 Much of the current theory of adaptation is based on Gillespie's mutational landscape model (MLM), which assumes that the fitness values of genotypes linked by single mutational steps are independent random variables. On the other hand, a growing body of
Krug, Joachim +2 more
core +1 more source
Genetic instability and transitional cell carcinoma of the bladder
BJU International, 2003 The development of cancer occurs in a stepwise fashion, with each step representing the mutation in one of several key genes. However, the mutation rate of somatic cells is too low to account for the number of mutations required for a cell to undergo carcinogenesis.
Catto, J, Meuth, M, Hamdy, F
openaire +2 more sources
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
IT Complexity Revolution: Intelligent Tools for the Globalised World Development
, 2009 Globalised-civilisation interaction intensity grows exponentially, involving all dimensions and regions of planetary environment. The resulting dynamics of critically high, exploding complexity urgently needs consistent understanding and efficient ...
Kirilyuk, Andrei, Ulieru, Mihaela
core +4 more sources
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Theranostics: A treasured tailor for tomorrow
Journal of Pharmacy and Bioallied Sciences, 2014 Emerging as a targeted, safe, and efficient pharmacotherapy is the approach of theranostics, which focuses on patient-centered care. It is a combination of diagnosis and therapeutics.
S Jeelani +5 more
doaj +1 more source
Stochastic slowdown in evolutionary processes
, 2010 We examine birth--death processes with state dependent transition probabilities and at least one absorbing boundary. In evolution, this describes selection acting on two different types in a finite population where reproductive events occur successively.
Arne Traulsen +14 more
core +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source