Results 81 to 90 of about 451,806 (340)
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Understanding the biology of urothelial cancer metastasis
Asian Journal of Urology, 2016 Management of unresectable urothelial cancer (UC) has been a clinical challenge for decades. While drug resistance is a key issue, precise understanding of biology of UC metastasis is another challenge for the improvement of treatment outcome of UC ...
Takashi Kobayashi
doaj
Anthocyanin contents and molecular changes in rose petals during the post-anthesis color transition
Ornamental Plant ResearchFlower color transitions during anthesis are taxonomically widespread; however, the mechanisms underlying post-anthesis color transition in roses are unclear.
Ying Kong +5 more
doaj +1 more source
Genetically Transitional Disease and the Road to Personalized Medicine
GenesGenetically transitional disease (GTD) is emerging as a new concept in genomic medicine to straddle between the traditional binary classification of monogenic and polygenic disease. Genetic testing result reports in molecular laboratories have been predicated on the monogenic disease model, which focuses on pathogenic and likely pathogenic variants ...
Qingping Yao +2 more
openaire +2 more sources
Living with phenylketonuria in adulthood: the PKU ATTITUDE study [PDF]
, 2018 Dietary treatment is the cornerstone of therapy for phenylketonuria (PKU), but adherence to low- phenylalanine diet progressively decreases after adolescence.
Bensi, Giulia +11 more
core +2 more sources
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Wright-fisher-like models with constant population size on average [PDF]
, 2017 We first recall some basic facts from the theory of discrete-time Markov chains arising from two types neutral and non-neutral evolution models of population genetics with constant size.
Grosjean, Nicolas, Huillet, Thierry
core +2 more sources
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Theranostics: A treasured tailor for tomorrow
Journal of Pharmacy and Bioallied Sciences, 2014 Emerging as a targeted, safe, and efficient pharmacotherapy is the approach of theranostics, which focuses on patient-centered care. It is a combination of diagnosis and therapeutics.
S Jeelani +5 more
doaj +1 more source
Multivariate, region‐based genetic analyses of facets of reproductive aging in White and Black women
Molecular Genetics & Genomic Medicine, 2022 Background Age at final menstrual period (FMP) and the accompanying hormone trajectories across the menopause transition do not occur in isolation, but likely share molecular pathways.
Lawrence F. Bielak +6 more
doaj +1 more source