Results 61 to 70 of about 2,228,086 (285)
, 2017 As Lao PDR prepares to graduate from Least Developed Country (LDC) status by 2020 to become an upper-middle-income country by 2030, it also expects to face declining funding from external sources and the need to increase domestic financing for health.
openaire +3 more sources
Facing the Adaptive Management Challenge: Insights from Transition Management
Ecology and Society, 2007 Recent research suggests that transitions toward adaptive water management regimes are needed because current water management regimes cannot adequately respond to uncertainty. The pivotal question is how to understand and manage such transitions.
Rutger van der Brugge, Roel van Raak
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Foreign direct investment: a tool or a target for industrial policy in Eastern Countries? [PDF]
, 1995 Is there any linkage between industrial policy and the inflow of Foreign Direct Investment in Eastern European countries? This is the core question which is analysed and discussed in this paper.
Soares, M. Isabel R. T.
core
Forest management after the economic transition [PDF]
, 2009 Germany and Scandinavia represent two paradigmatic forest management traditions, based on management for volume and management for profit, respectively.
Brukas, Vilis, Weber, Norbert
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Conceptualizing, Observing, and Influencing Social-Ecological Transitions
Ecology and Society, 2009 This article creates a meeting ground between two distinct and fairly elaborate research traditions dealing with social "transitions": the Dutch societal transitions management approach, and the Viennese sociometabolic transitions approach.
Marina Fischer-Kowalski, Jan Rotmans
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Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
, 2004 «Challenges to Collective Security» Working Papers from NUPI’s UN Programme: The emerging consensus on the need to establish more effective United Nations mechanisms for managing the transition from conflict to peace, and on the importance of addressing the nexus between development and security, is not sufficiently reflected in the organisational ...
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