Results 91 to 100 of about 4,558,660 (292)

Transition function for the Toda chain model

open access: yes, 2006
The method of Lambda-operators developed by S. Derkachov, G. Korchemsky, A. Manashov is applied to a derivation of eigenfunctions for the open Toda chain.
A. Gerasimov   +13 more
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Chiral transition in a strongly coupled fermion-gauge-scalar model

open access: yes, 1994
We report the recent results from the computer simulations of a fermion-gauge-scalar model with dynamical chiral-symmetry breaking and chiral transition induced by the scalar field. This model might be considered to be a possible alternative to the Higgs
Azcoiti   +3 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Characterization of topological phase transitions via topological properties of transition points

open access: yes, 2015
We study topological properties of phase transition points of topological quantum phase transitions by assigning a topological invariant defined on a closed circle or surface surrounding the phase transition point in the parameter space of momentum and ...
Chen, Shu, Li, Linhu
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The depinning transition in presence of disorder: a toy model

open access: yes, 2014
We introduce a toy model, which represents a simplified version of the problem of the depinning transition in the limit of strong disorder. This toy model can be formulated as a simple renormalization transformation for the probability distribution of a ...
Derrida, Bernard, Retaux, Martin
core   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Continuous melting of compact polymers

open access: yes, 2004
The competition between chain entropy and bending rigidity in compact polymers can be addressed within a lattice model introduced by P.J. Flory in 1956.
B. Nienhuis   +11 more
core   +2 more sources

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