Results 61 to 70 of about 105,979 (259)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Observer-Based Asynchronous Guaranteed Cost Control of 2-D Markov Jump Roesser Systems With Nonideal Transition Probabilities

IEEE Access
This paper mainly investigates the asynchronous observer-based guaranteed cost control problem for two-dimensional Markov jump Roesser systems with nonideal transition probabilities.
Jiazheng Liu, Yang Yang, Yaru Song
doaj   +1 more source

TPmsm: Estimation of the Transition Probabilities in 3-State Models

Journal of Statistical Software, 2014
One major goal in clinical applications of multi-state models is the estimation of transition probabilities. The usual nonparametric estimator of the transition matrix for non-homogeneous Markov processes is the Aalen-Johansen estimator (Aalen and ...
Artur Araújo, Luís Meira-Machado, Javier Roca-Pardiñas   +2 more
doaj   +1 more source

Efficient algorithm to compute Markov transitional probabilities for a desired PageRank

EPJ Data Science, 2020
We propose an efficient algorithm to learn the transition probabilities of a Markov chain in a way that its weighted PageRank scores meet some predefined target values.
Gábor Berend
doaj   +1 more source

Transition probabilities.

, 2015
Abbreviation: MTESS = mobile telemedicine-enabled screening and surveillance;Transition probabilities.
Nigel R. Armfield (799889), Paul A. Scuffham (386394), Kim-Huong Nguyen (290474), Mark Bensink (799890), Anthony C. Smith (799888)   +4 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Optical Transition Probabilities of Er3+ Ions in ErBa3B9O18 Crystal

Journal of Spectroscopy, 2015
The optical absorption and emission intensity of luminescent and birefringent crystal ErBa3B9O18 were examined from optical absorption data based on Judd-Ofelt theory. The three intensity parameters Ωt (t=2,4,6) are 3.10 × 10−20, 0.87 × 10−20, and 1.80 ×
Ming He, Tiezheng Liu, Junling Xiu, Yuanguang Tang, Zhihua Zhang   +4 more
doaj   +1 more source

Transition probabilities.

, 2013
Transition probabilities for the different events appearing in the master equation (5).
Rémi Lehe (327966), Oskar Hallatschek (227781), Luca Peliti (327969)   +2 more
core   +1 more source