Results 51 to 60 of about 105,979 (259)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
BMC GeriatricsBackground The instrumental activities of daily living (IADL) among the elderly have been found to be heterogeneous, with different trajectories. However, the transition of the IADL over time remains unclear.
Yaqi Wang +8 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Multiplatform Computing of Transition Probabilities in Os V
AtomsOsmium is an element of the Periodic Table with an atomic number Z equal to 76. In Tokamaks with divertors made of tungsten (Z=74), it is produced in the neutron-induced transmutation of the latter.
Patrick Palmeri +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Discrete-time neural Markov models
BMC Medical Research MethodologyBackground Markov models can be used to describe the movement of individuals between states. In medicine, Markov models are used to describe, for example, disease progression and the effects of interventions on such progression. The models can further be
Jesper Sundell +2 more
doaj +1 more source
Non Unitary Random Walks [PDF]
Discrete Mathematics & Theoretical Computer Science, 2009 Motivated by the recent refutation of information loss paradox in black hole by Hawking, we investigate the new concept of {\it non unitary random walks}.
Philippe Jacquet
doaj +1 more source
Transition Probabilities of Neutral Scandium [PDF]
, 2014 WOS:000344602200021The electric dipole transition probabilities and the oscillator strengths of neutral scandium have been calculated using the quantum defect orbital theory and the Cowan code for the 3d4s(2)-3d4s4p, 3d(2)4s-3d(2)4p, and 3d4s(2)-4s(2)4p ...
Celik, G. +14 more
core +1 more source