Results 51 to 60 of about 490,730 (291)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Markov chains as a proxy for the predictive memory representations underlying mismatch negativity

Frontiers in Human Neuroscience, 2023
Events not conforming to a regularity inherent to a sequence of events elicit prediction error signals of the brain such as the Mismatch Negativity (MMN) and impair behavioral task performance.
Erich Schröger, Urte Roeber, Nina Coy, Nina Coy   +3 more
doaj   +1 more source

Transitional probability and phoneme monitoring [PDF]

4th International Conference on Spoken Language Processing (ICSLP 1996), 1996
Two phoneme monitoring experiments examined the influence of transitional probability (TP) on phoneme recognition. Target phonemes appeared at the end of consonant-vowel-consonant (CVC) syllables, or as the first element of coda clusters in CVCC syllables. Reliable TP effects were found only for targets in CVCC syllables.
James M. McQueen, Mark A. Pitt
openaire   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Calculated oscillator strengths and transition probabilities of singly ionised nickel (Ni II)

Astronomy & Astrophysics
Aims. This work reports calculated transition probabilities for spectral lines of singly ionised nickel (Ni II) incorporating newly determined experimental energy levels, addressing critical gaps in atomic data required for astrophysical spectroscopy and
Clear Christian P., Uylings Peter, Raassen Ton   +2 more
doaj   +1 more source

Basic parametric analysis for a multi-state model in hospital epidemiology

BMC Medical Research Methodology, 2017
Background The extended illness-death model is a useful tool to study the risks and consequences of hospital-acquired infections (HAIs). The statistical quantities of interest are the transition-specific hazard rates and the transition probabilities as ...
Maja von Cube, Martin Schumacher, Martin Wolkewitz   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Spacetime structures of continuous time quantum walks [PDF]

, 2005
The propagation by continuous time quantum walks (CTQWs) on one-dimensional lattices shows structures in the transition probabilities between different sites reminiscent of quantum carpets. For a system with periodic boundary conditions, we calculate the
Blumen, Alexander, Muelken, Oliver
core   +1 more source

Transition probabilities in argon I

Journal of Research of the National Bureau of Standards Section A: Physics and Chemistry, 1967
In order to derive transition probabilities from intensity measurements of Ar I lines made by Dieke and Crosswhite, new transition probabilities for 26 lines from high levels in Ar I have been measured in a high current constricted arc. With these data, relative level populations of Ar I in Dieke and Crosswhite's rnicrewave discharge are determined and
C H, Corliss, J B, Shumaker
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source