Results 51 to 60 of about 1,476,337 (273)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Maintaining the water consumption, in an urban system: A probabilistic approach is applied

Journal of Water and Land Development, 2017
An urban system is influenced by many disruptions that may cause failures for it, in the end. In order to maintain continuity of its operations, analysis of its components operation becomes very necessary.
Selmani Bouayoune Karima, Boudi El Mostapha, Bachir Aziz   +2 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Benefits and risks of clofarabine in adult acute lymphoblastic leukemia investigated in depth by multi‐state modeling

Cancer Medicine
Background We recently reported results of the prospective, open‐label HOVON‐100 trial in 334 adult patients with acute lymphoblastic leukemia (ALL) randomized to first‐line treatment with or without clofarabine (CLO).
Sjoerd J. F. Hermans, Yvette vanNorden, Jurjen Versluis, Anita W. Rijneveld, Bronno van derHolt, Okke deWeerdt, Bart J. Biemond, Arjan A. van deLoosdrecht, Lotte E. van derWagen, Mar Bellido, Michel vanGelder, Walter J. F. M. van derVelden, Dominik Selleslag, Daniëlle vanLammeren‐Venema, Vincent H. J. van derVelden, Liesbeth C. deWreede, Douwe Postmus, Francesco Pignatti, Jan J. Cornelissen   +18 more
doaj   +1 more source

Tunneling between fermionic vacua and the overlap formalism [PDF]

, 1996
The probability amplitude for tunneling between the Dirac vacua corresponding to different signs of a parity breaking fermionic mass $M$ in $2+1$ dimensions is studied, making contact with the continuum overlap formulation for chiral determinants.
Alvarez-Gaume, C.D. Fosco, Fosco, Fosco, Fradkin, Jansen, Kaplan, Karsten, Karsten, Narayanan, Narayanan, Neuberger, Nielsen, Nielsen, Nielsen, Rajaraman, Randjbar-Daemi, Shamir, Zinn-Justin   +18 more
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Annotations of two examples about Markov process [PDF]

, 2013
In this paper, we discuss an incorrect example that a Markov process does not satisfy strong Markov property, and analyzes the reason of mistake.
Tang, Rong
core  

Yang-Lee zeros for a nonequilibrium phase transition [PDF]

, 2002
Equilibrium systems which exhibit a phase transition can be studied by investigating the complex zeros of the partition function. This method, pioneered by Yang and Lee, has been widely used in equilibrium statistical physics.
Alves N A, Alves N A, Dickman R, Ghyka M, Griffiths R B, Haye Hinrichsen, Henkel M, Hinrichsen H, Jensen I, Kinzel W, Marro J, Ozorio de Almeida A M, Rupp P, Schroeder M, Silvio R Dahmen, Stephan M Dammer, Vajda S, Voigt C A   +17 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source