Results 121 to 130 of about 2,507,189 (293)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Estimating multistate transition rates from population distributions

Demographic Research, 2003
The ability to estimate transition rates (or probabilities) from population distributions has many potential applications in demography. Iterative Proportional Fitting (IPF) has been used for such estimation, but lacks a meaningful behavioral, or ...
doaj  

Stochastic analysis of a COVID-19 model with effects of vaccination and different transition rates: Real data approach. [PDF]

Chaos Solitons Fractals, 2023
Xu C, Liu Z, Pang Y, Akgül A.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A theoretical framework to analyse the flow of particles in a dynamical system with stochastic transition rates and site capacities. [PDF]

R Soc Open Sci, 2022
Jain A, Kumar A, Kumar Gupta A.
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Dissipation bounds the amplification of transition rates far from equilibrium. [PDF]

Proc Natl Acad Sci U S A, 2021
Kuznets-Speck B, Limmer DT.
europepmc   +1 more source

Fertility, Mortality, and the Developed World’s Demographic Transition [PDF]

This study uses Fehr, Jokisch, and Kotlikoff’s (2004a) dynamic general equilibrium model to analyze the effects of changes in fertility and mortality on the developed world’s demographic transition. The model features three regions – the U.S., Japan, and
Hans Fehr, Laurence Kotlikoff, Sabine Jokisch   +2 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Daylight Saving Time Practice and the Rate of Adverse Cardiovascular Events in the United States: A Probabilistic Assessment in a Large Nationwide Study

Mayo Clinic Proceedings: Innovations, Quality & Outcomes
We investigated the association of daylight saving time (DST) transitions with the rates of adverse cardiovascular events in a large, US-based nationwide study.
Benjamin A. Satterfield, MD, PhD, Ozan Dikilitas, MD, Holly Van Houten, BA, Xiaoxi Yao, PhD, MPH, Bernard J. Gersh, MBChB, DPhil   +4 more
doaj   +1 more source