Results 81 to 90 of about 5,147,352 (245)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Transitional Jobs Reentry Demonstration: Advancing the Field of Transitional Jobs [PDF]
, 2010 The field of Transitional Jobs (TJ) is committed to providing employment opportunities to people throughout our nation who have struggled to find or keep a job. The National Transitional Jobs Network is committed to helping practitioners implement tested
core +2 more sources
Frontiers in Immunology, 2018 The follicular (FO) versus marginal zone (MZ) B cell fate decision in the spleen depends upon BCR, BAFF, and Notch2 signaling. Whether or how Gi signaling affects this fate decision is unknown.
Il-Young Hwang +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Urothelial Tumours of the Urinary Bladder: A Histopathological Study of Cystoscopic Biopsies
Journal of Nepal Medical Association, 2013 Introduction: Bladder tumours constitute one of the most common urological conditions. Urothelial (transitional cell) carcinoma accounts for 90% of all primary tumours of the bladder. These tumours are an important cause of morbidity and mortality.
Sujan Vaidya +3 more
doaj +3 more sources
International Brazilian Journal of Urology, 2006 OBJECTIVE: To analyze the results of the treatment of transitional cell carcinoma (TCC) of the bladder with radical cystectomy and determine which prognostic factors can be utilized as disease-free survival and cancer-specific survival independent ...
Antunes Alberto A. +7 more
doaj
Correlation between human papillomavirus infection and bladder transitional cell carcinoma
BMC Infectious Diseases, 2005 Background To determine the association of human papillomavirus infection (HPV) and transitional cell carcinoma (TCC). Methods Using polymerase chain reaction, fifty-nine bladder tissue specimens of patients with transitional cell carcinoma of bladder ...
Moghaddam SMM Hosseini +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Explicit Transitional Dynamics in Growth Models [PDF]
Transitional dynamics in growth models have been subject to much attention recently. With a few exceptions, existing studies rely on computational techniques.
Danyang Xie
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source