Results 91 to 100 of about 84,662 (294)

Sporadic Dips from Extended Debris Transiting the Metal-rich White Dwarf SBSS 1232+563

open access: yesThe Astrophysical Journal
We present the discovery of deep but sporadic transits in the flux of SBSS 1232+563, a metal-rich white dwarf polluted by disrupted exoplanetary debris.
J. J. Hermes   +7 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Affective transits in contemporary poetry: cartography, highlights and pathways

open access: yesGragoatá, 2012
This article inquires about the strong presence of art works, especially in contemporary poetry, that proposes a relational or collective way of reading and writing, that opens the notions of voice and subjectivity to the encounters with the other, sho ...
Luciana María Di Leone
doaj  

TOI 762 A b and TIC 46432937 b: Two Giant Planets Transiting M-dwarf Stars

open access: yesThe Astronomical Journal
We present the discovery of TOI 762 A b and TIC 46432937 b, two giant planets transiting M-dwarf stars. Transits of both systems were first detected from observations by the NASA TESS mission, and the transiting objects are confirmed as planets through ...
Joel D. Hartman   +35 more
doaj   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

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