Results 121 to 130 of about 84,662 (294)

Study on the Nonlinear Vibration Characteristic of Bending-torsional Coupled Single-stage Gear

open access: yesJixie chuandong, 2019
Taking spur gear pair as the research object, a 6-DOF coupled bending-torsion nonlinear vibration model including time-varying meshing stiffness, comprehensive error, backlash and input torque is established. Based on the bifurcation diagram and Poincare
Rongju Liu   +3 more
doaj  

Short-period Small Planets with High Mutual Inclinations are More Common around Metal-rich Stars

open access: yesThe Astrophysical Journal Letters
We present a correlation between the stellar metallicities and the mutual inclinations of multiplanet systems hosting short-period small planets ( a / R _⋆  
Xinyan Hua   +9 more
doaj   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Probing Two-dimensional Asymmetries of an Exoplanet Atmosphere from Chromatic Transit Variation

open access: yesThe Astronomical Journal
We propose a new method for investigating atmospheric inhomogeneities in exoplanets through transmission spectroscopy. Our approach links chromatic variations in conventional transit model parameters—central transit time, total and full durations, and ...
Shotaro Tada   +4 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren   +16 more
wiley   +1 more source

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