Results 121 to 130 of about 140,835 (316)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Sporadic Dips from Extended Debris Transiting the Metal-rich White Dwarf SBSS 1232+563

The Astrophysical Journal
We present the discovery of deep but sporadic transits in the flux of SBSS 1232+563, a metal-rich white dwarf polluted by disrupted exoplanetary debris.
J. J. Hermes, Joseph A. Guidry, Zachary P. Vanderbosch, Mariona Badenas-Agusti, Siyi Xu, Malia L. Kao, Antonio C. Rodriguez, Keith Hawkins   +7 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

TOI 762 A b and TIC 46432937 b: Two Giant Planets Transiting M-dwarf Stars

The Astronomical Journal
We present the discovery of TOI 762 A b and TIC 46432937 b, two giant planets transiting M-dwarf stars. Transits of both systems were first detected from observations by the NASA TESS mission, and the transiting objects are confirmed as planets through ...
Joel D. Hartman, Daniel Bayliss, Rafael Brahm, Edward M. Bryant, Andrés Jordán, Gáspár Á. Bakos, Melissa J. Hobson, Elyar Sedaghati, Xavier Bonfils, Marion Cointepas, Jose Manuel Almenara, Khalid Barkaoui, Mathilde Timmermans, George Dransfield, Elsa Ducrot, Sebastián Zúñiga-Fernández, Matthew J. Hooton, Peter Pihlmann Pedersen, Francisco J. Pozuelos, Amaury H. M. J. Triaud, Michaël Gillon, Emmanuel Jehin, William C. Waalkes, Zachory K. Berta-Thompson, Steve B. Howell, Elise Furlan, George R. Ricker, Roland Vanderspek, Sara Seager, Joshua N. Winn, Jon M. Jenkins, David Rapetti, Karen A. Collins, David Charbonneau, Christopher J. Burke, David R. Rodriguez   +35 more
doaj   +1 more source

Peculiarities of study of Au–Ti–Pd–n+-n-n+-Si multilayer contact structure to avalanche transit-time diodes [PDF]

, 2019
P. M. Romanets
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Decreased gastric emptying and gastrointestinal and intestinal transits of liquid after complete spinal cord transection in awake rats

Brazilian Journal of Medical and Biological Research, 1998
We studied the effect of complete spinal cord transection (SCT) on gastric emptying (GE) and on gastrointestinal (GI) and intestinal transits of liquid in awake rats using the phenol red method.
Gondim F. de-A.A., da-Graça J.R.V., de-Oliveira G.R., Rêgo M.C.V., Gondim R.B.M., Rola F.H.   +5 more
doaj  

A Deep Search for Exomoons around WISE 0855 with JWST

The Astronomical Journal
The James Webb Space Telescope (JWST) is collecting time-series observations of many free-floating planets (FFPs) to study their weather, but these light curves provide ideal datasets for locating exomoons that transit FFPs during observations.
Mikayla J. Wilson, Mary Anne Limbach, Andrew J. Skemer, Johanna M. Vos, Brittany E. Miles, Melanie J. Rowland, Andrew Vanderburg, Adam C. Schneider, Caroline Morley, Brooke Kotten, Andrew Householder, Roxana Lupu, James Mang, Richard Freedman   +13 more
doaj   +1 more source

Transit oriented development: theory and implementation challenges in Ghana.

, 2020
Kwabena Koforobour Agyemang, Regina Obilie Amoako‐Sakyi, Kwabena Barima Antwi, Collins Adjei Mensah, Albert Abane   +4 more
openalex   +2 more sources