Results 101 to 110 of about 394,172 (251)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Validação do "King's Health Questionnaire" para o português em mulheres com incontinência urinária

Revista de Saúde Pública
OBJETIVO: Traduzir e adaptar para o português o questionário de qualidade de vida denominado "King's Health Questionnaire" (KHQ) em mulheres com incontinência urinária.
José Tadeu Nunes Tamanini, Carlos Arturo Levi D'Ancona, Neury José Botega, Nelson Rodrigues Netto Jr   +3 more
doaj  

Translating between trans-ferring and trans-forming

Bucharest Working Papers in Linguistics, 2010
This paper analyzes the role of translators/interpreters in a world in which intercultural exchanges have multiplied dramatically. If traditionally the translator has been a mediator between different linguistic and cultural universes, his role is even ...
Dan Mateescu
doaj  

Impacts of dietary animal and plant protein on weight and glycemic control in health, obesity and type 2 diabetes: friend or foe?

Frontiers in Endocrinology
It is well established that high-protein diets (i.e. ~25–30% of energy intake from protein) provide benefits for achieving weight loss, and subsequent weight maintenance, in individuals with obesity, and improve glycemic control in type 2 diabetes (T2D).
Javad Anjom-Shoae, Christine Feinle-Bisset, Michael Horowitz, Michael Horowitz   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Translating Cultures: theme update, July 2014

, 2014
Since the ‘Translating Cultures’ symposium held in March, activity linked to the theme has continued to evolve rapidly. I will soon be able to provide details of the innovation awards granted following the close of the call in March 2014, and look ...
Charles Forsdick
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Interpretive use: translating intensification

, 2001
My aim here is to discuss first the fitness of a cognitive theory like RT when approaching the interpretive operations taking place in the translating activity. The basic notion of interpretive resemblance is put forward instead of the traditional one of
López Folgado, Vicente
core   +1 more source

"Make it new": When Luigi Meneghello transplanted “silly” Yeats

Studi Irlandesi
The essay explores how Meneghello translated some of Yeats’s poems into the dialect of Vicenza. Yeats’s compositions became a source of sustenance for the poet from Malo, offering profound insights into various aspects of life and art.
Arianna Antonielli
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source