This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Translating metaphors into Afrikaans in a source language-oriented translation of the Hebrew Bible
Van der Merwe, Christo H. J. +1 more
doaj +1 more source
Errors in algebraic statements translation during the creation of an algebraic domino [PDF]
We present a research study which main objective is to inquire into secondary school students´ ability to translate and relate algebraic statements which are presented in the symbolic and verbal representation systems.
Castro, Encarnación +3 more
core
YIPFα1A expression is regulated by multilayered molecular mechanisms
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Parallels Between Goffman’s Interaction Order and Interpreting Interaction in Community Interpreting
The aim of this paper is to descriptively show to what extent the interaction sociological approach of the interaction order, developed by the American sociologist Erving Goffman, has points of contact with interpreter interaction in community ...
Yelda Arkan
doaj +1 more source
Sworn translators and interpreters in the legal field, mutually exclusive? [PDF]
Este trabajo pretende ser una reflexión sobre cómo dos profesiones que, a pesar de compartir una base común, en el mundo académico aparecen a menudo separadas por determidas competencias bien definidas y divergentes entre sí.
García-Luque, Francisca
core
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Training refugees to become interpreters for refugees
RMIT University, Translating and Interpreting Program in partnership with the Victorian Multicultural Commission (VMC, formerly Victorian Office of Multicultural Affairs or VOMA), has been offering a National Australian Authority for Translators and ...
Miranda Lai, Sedat Mulayim
doaj
Community Interpreting Training in Türkiye: A Study Based on the Views of Academics and Interpreters
Health tourism along with cultural tourism, educational opportunities, natural disasters, and recent conflicts in the region have made community interpreting an indispensable service in Türkiye. This rise in the sector should also, in correlation, affect
Gizem Yaren Kutlu +1 more
doaj +1 more source

