Results 51 to 60 of about 4,175,323 (327)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Safety of pharmacologic interventions for neuropsychiatric symptoms in dementia: a systematic review and network meta-analysis

BMC Geriatrics, 2020
Background Prescribing trends suggest that pharmacologic alternatives to antipsychotics are gaining in popularity, but randomized trial (RCT) data of their comparative safety is scarce.
Jennifer A. Watt, Zahra Goodarzi, Areti Angeliki Veroniki, Vera Nincic, Paul A. Khan, Marco Ghassemi, Yuan Thompson, Yonda Lai, Victoria Treister, Andrea C. Tricco, Sharon E. Straus   +10 more
doaj   +1 more source

E-COMMERCE CONNECTING CHINA AND LATIN AMERICA VIA DIGITAL SILK-ROAD

Revista Cubana de Administración Pública y Empresarial, 2022
Latin America is the natural extension of the “Maritime Silk Road” and its exchanges and cooperation with China have become increasingly frequent in recent years.
Xiaoyu Li , Yajie Wu, Yifan Wang, Yuexuan Wang, Tong Wen   +4 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds

Scientific Reports, 2020
The ability to produce constructs with a high control over the bulk geometry and internal architecture has situated 3D printing as an attractive fabrication technique for scaffolds.
Amir Seyedsalehi, Leila Daneshmandi, Mohammed Barajaa, John Riordan, Cato T. Laurencin   +4 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Current landscape of mRNA technologies and delivery systems for new modality therapeutics

Journal of Biomedical Science
Realizing the immense clinical potential of mRNA-based drugs will require continued development of methods to safely deliver the bioactive agents with high efficiency and without triggering side effects.
Ruei-Min Lu, Hsiang-En Hsu, Ser John Lynon P. Perez, Monika Kumari, Guan-Hong Chen, Ming-Hsiang Hong, Yin-Shiou Lin, Ching-Hang Liu, Shih-Han Ko, Christian Angelo P. Concio, Yi-Jen Su, Yi-Han Chang, Wen-Shan Li, Han-Chung Wu   +13 more
doaj   +1 more source

Frailty, delirium and hospital mortality of older adults admitted to intensive care: the Delirium (Deli) in ICU study

Critical Care, 2020
Background Clinical frailty among older adults admitted to intensive care has been proposed as an important determinant of patient outcomes. Among this group of patients, an acute episode of delirium is also common, but its relationship to frailty and ...
David Sanchez, Kathleen Brennan, Masar Al Sayfe, Sharon-Ann Shunker, Tony Bogdanoski, Sonja Hedges, Yu Chin Hou, Joan Lynch, Leanne Hunt, Evan Alexandrou, Manoj Saxena, Simon Abel, Ramanathan Lakshmanan, Deepak Bhonagiri, Michael J. Parr, Anders Aneman, Danielle Ni Chroinin, Kenneth M. Hillman, Steven A. Frost   +18 more
doaj   +1 more source

Technical Infrastructures of Historical Translation Knowledge: A Call for the use of the Digital Library and Bibliography of Literature in Translation

Chronotopos, 2022
Editorial in English and German on the technical infrastructures relevant for translation history. The editors share an invitation to make use of the Digital Library and Bibliography of Literature in Translation (DLBT) and discuss the needs of ...
Larisa Schippel, Julia Richter, Tomasz Rozmyslowicz , Stefanie Kremmel   +3 more
doaj   +1 more source

Limitless translation limits translation [PDF]

Nature, 2017
Evidence has now been found that ribosomes — the cell’s translational apparatus — can pass beyond the main protein-coding region of messenger RNAs to form ‘traffic jams’ that inhibit protein expression. Evidence has now been found that ribosomes — the cell’s translational apparatus — can pass beyond the main protein-coding region of messenger RNAs to ...
openaire   +2 more sources