Results 21 to 30 of about 3,070,291 (402)
LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy
Nature Communications, 2022 LC3/ATG8 plays an essential role in autophagy. Here the authors show that LC3B exhibits RNA-binding ability and induces rapid degradation of target mRNAs via autophagic activation, highlighting the interplay between autophagy and RNA biology.
Hyun Jung Hwang +5 more
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Translation inhibition by rocaglates activates a species-specific cell death program in the emerging fungal pathogen Candida auris [PDF]
, 2020 Fungal infections are a major contributor to infectious disease-related deaths worldwide. Recently, global emergence of the fungal pathogen Candida auris has caused considerable concern because most C.
Brown, Lauren E. +6 more
core +1 more source
Antibody cocktail effective against variants of SARS-CoV-2
Journal of Biomedical Science, 2021 Background Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an RNA virus with a high mutation rate.
Kang-Hao Liang +10 more
doaj +1 more source
Heliyon, 2023 The COVID-19 pandemic continues to threaten human health worldwide as new variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge. Currently, the predominant circulating strains around the world are Omicron variants, which can
Ruei-Min Lu +11 more
doaj +1 more source
Genetics of coronary artery disease: discovery, biology and clinical translation
Nature reviews genetics, 2017 Amit V. Khera, Sekar Kathiresan
openalex +3 more sources
Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation
Nature Communications, 2020 Nonsense-mediated mRNA decay (NMD) is a translation-coupled process that eliminates mRNAs containing premature translation-termination codons. Here the authors identify a role for the NMD factor UPF1 in protein quality control, whereby truncated ...
Yeonkyoung Park +7 more
doaj +1 more source
Telomere biology and translational research [PDF]
Translational Research, 2013 Origins. The appreciation that there might be something special about chromosome ends began in the 1930s through 2 independent observations. Herman Muller, working with fruit flies, noticed that x rays caused chromosome breakages and that the broken ends subsequently fused with each other. He noticed that the real ends of chromosomes never took part in
Philip J, Mason, Nieves, Perdigones
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Journal of Biomedical Science, 2023 mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high efficiency and without activating the immune ...
Yu-Shiuan Wang +6 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Cell-free biology is increasingly utilized for engineering biological systems, incorporating novel functionality, and circumventing many of the complications associated with cells. The central dogma describes the information flow in biology consisting of
Ragunathan Bava Ganesh +1 more
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Genes & Development, 2020 In this review, Kim et al. discuss the importance of PARP family members and ADPRylation in gene regulation, mRNA processing, and protein abundance.
Dae-Seok Kim +3 more
semanticscholar +1 more source