Results 21 to 30 of about 2,436,936 (150)
Natural variability of Kozak sequences correlates with function in a zebrafish model. [PDF]
PLoS ONE, 2014 In eukaryotes, targeting the small ribosomal subunit to the mRNA transcript requires a Kozak sequence at the translation initiation site. Despite the critical importance of the Kozak sequence to regulation of gene expression, there have been no ...
Steven J Grzegorski +4 more
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The genetics of obesity: from discovery to biology
Nature reviews genetics, 2021 The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people’s health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases.
R. Loos, G. Yeo
semanticscholar +1 more source
Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation
Nature Cell Biology, 2018 N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate.
Huilin Huang +29 more
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Predicting translation initiation rates for designing synthetic biology
Frontiers in Bioengineering and Biotechnology, 2014 In synthetic biology, precise control over protein expression is required in order to construct functional biological systems. A core principle of the synthetic biology approach is model-guided design and, based on biological understanding of the process,
Benjamin eReeve +5 more
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Journal of Biomedical Science, 2022 Background With the continuous emergence of new SARS-CoV-2 variants that feature increased transmission and immune escape, there is an urgent demand for a better vaccine design that will provide broader neutralizing efficacy.
I-Jung Lee +40 more
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Frontiers in Immunology, 2022 Boosting Bacillus Calmette-Guérin (BCG) with subunit vaccine is expected to induce long-term protection against tuberculosis (TB). However, it is urgently needed to optimize the boosting schedule of subunit vaccines, which consists of antigens from or ...
Wei Lv +12 more
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New Perspectives on Reverse Translation: Brief History and Updates
Universitas Scientiarum, 2023 Since the 1950s, reverse translation has been an enigmatic part of Crick’s central dogma of molecular biology. It might be described as the possibility to back-translate information from proteins to nucleic acids (or codons).
Adhityo Wicaksono +2 more
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The biology of frailty in humans and animals: Understanding frailty and promoting translation
Aging Medicine, 2019 Frailty is a state of high vulnerability to adverse health outcomes. This concept is used to explain the heterogeneity in rates of aging in people of the same age.
E. Bisset, S. Howlett
semanticscholar +1 more source
Miniaturizing chemistry and biology using droplets in open systems
Nature Reviews Chemistry, 2023 Open droplet microfluidic systems manipulate droplets on the picolitre-to-microlitre scale in an open environment. They combine the compartmentalization and control offered by traditional droplet-based microfluidics with the accessibility and ease-of-use
Yuting Zeng +7 more
semanticscholar +1 more source
Building the UK's industrial base in engineering biology
Engineering Biology, 2021 The paper describes the strategy and components that have been put in place to build the UK's research and industrial base in Engineering Biology. The initial section of the paper provides a brief historical overview of the development of the field in ...
Richard I. Kitney
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