Results 21 to 30 of about 2,991,765 (400)
Journal of Biomedical Science, 2023 mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high efficiency and without activating the immune ...
Yu-Shiuan Wang +6 more
doaj +1 more source
Genes & Development, 2020 In this review, Kim et al. discuss the importance of PARP family members and ADPRylation in gene regulation, mRNA processing, and protein abundance.
Dae-Seok Kim +3 more
semanticscholar +1 more source
The Elements of Translational Chemical Biology [PDF]
Cell Chemical Biology, 2018 A causal relationship between target activity modulation by small molecules and phenotypic consequence is the cornerstone of chemical biology and drug discovery. Here we articulate elements of translational chemical biology, as guideposts to ensure the appropriate use of chemical probes and the conclusions drawn from cellular studies with these ...
P. Ann Boriack-Sjodin +1 more
openaire +2 more sources
Proximity-Based Modalities for Biology and Medicine
ACS Central Science, 2023 Molecular proximity orchestrates biological function, and blocking existing proximities is an established therapeutic strategy. By contrast, strengthening or creating neoproximity with chemistry enables modulation of biological processes with high ...
Xingui Liu, A. Ciulli
semanticscholar +1 more source
Telomere biology and translational research [PDF]
Translational Research, 2013 Origins. The appreciation that there might be something special about chromosome ends began in the 1930s through 2 independent observations. Herman Muller, working with fruit flies, noticed that x rays caused chromosome breakages and that the broken ends subsequently fused with each other. He noticed that the real ends of chromosomes never took part in
Nieves Perdigones, Philip J. Mason
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eIF2B-capturing viral protein NSs suppresses the integrated stress response
Nature Communications, 2021 Here the authors show that a viral protein interferes with the binding of phosphorylated eIF2 to eIF2B, thereby suppressing the host integrated stress response (ISR). This suppression of the ISR abrogates translational changes of the host and ameliorates
Kazuhiro Kashiwagi +10 more
doaj +1 more source
Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system. [PDF]
, 2017 Stem cell-derived cardiomyocytes provide a promising tool for human developmental biology, regenerative therapies, disease modeling, and drug discovery.
Gimzewski, James K +7 more
core +2 more sources
The emerging role of RNA modifications in the regulation of mRNA stability
Experimental and Molecular Medicine, 2020 Gene activity: the significance of RNA modification Messenger RNA molecules play their key role in directing the manufacture of proteins via translating the genetic information in DNA.
Sung Ho Boo, Yoon Ki Kim
doaj +1 more source
Novel capsid binder and PI4KIIIbeta inhibitors for EV-A71 replication inhibition
Scientific Reports, 2021 The Hand, Foot and Mouth Disease (HFMD) is a highly contagious viral illness generally manifests as a mild disease in young children and immunocompromised adults.
Yong Wah Tan +5 more
doaj +1 more source
The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans [PDF]
, 2011 Despite the importance of microRNAs (miRNAs) in gene regulation, it is unclear how the miRNA-Argonaute complex-or miRNA-induced silencing complex (miRISC)-can regulate the translation of their targets in such diverse ways.
Bajan, Sarah +7 more
core +3 more sources