Results 21 to 30 of about 2,536,108 (315)
Hijacking Translation Initiation for Synthetic Biology
ChemBioChem, 2020 Genetic code expansion (GCE) has revolutionized the field of protein chemistry. Over the past several decades more than 150 different noncanonical amino acids (ncAAs) have been co‐translationally installed into proteins within various host organisms. The
Jeffery M. Tharp +3 more
semanticscholar +1 more source
Translation initiation consistency between in vivo and in vitro bacterial protein expression systems
Frontiers in Bioengineering and Biotechnology, 2023 Strict on-demand control of protein synthesis is a crucial aspect of synthetic biology. The 5′-terminal untranslated region (5′-UTR) is an essential bacterial genetic element that can be designed for the regulation of translation initiation.
Jiaojiao Li +10 more
doaj +1 more source
Stromal biology and therapy in pancreatic cancer: ready for clinical translation?
Gut, 2018 Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote tumour progression, metastasis niche formation and therapeutic resistance ...
A. Neesse +7 more
semanticscholar +1 more source
Stem cell research & therapeutics, 2017 Adipose/fat tissue provides an abundant source of stromal vascular fraction (SVF) cells for immediate administration and can also give rise to a substantial number of cultured, multipotent adipose-derived stromal cells (ADSCs).
Pablo Bora, A. Majumdar
semanticscholar +1 more source
The genetics of obesity: from discovery to biology
Nature reviews genetics, 2021 The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people’s health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases.
R. Loos, G. Yeo
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Predicting translation initiation rates for designing synthetic biology
Frontiers in Bioengineering and Biotechnology, 2014 In synthetic biology, precise control over protein expression is required in order to construct functional biological systems. A core principle of the synthetic biology approach is model-guided design and, based on biological understanding of the process,
Benjamin eReeve +5 more
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Natural variability of Kozak sequences correlates with function in a zebrafish model. [PDF]
PLoS ONE, 2014 In eukaryotes, targeting the small ribosomal subunit to the mRNA transcript requires a Kozak sequence at the translation initiation site. Despite the critical importance of the Kozak sequence to regulation of gene expression, there have been no ...
Steven J Grzegorski +4 more
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Biology-guided deep learning predicts prognosis and cancer immunotherapy response
Nature Communications, 2023 Substantial progress has been made in using deep learning for cancer detection and diagnosis in medical images. Yet, there is limited success on prediction of treatment response and outcomes, which has important implications for personalized treatment ...
Yuming Jiang +19 more
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The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases
Molecular Therapy: Nucleic Acids, 2021 YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms,
Zuyao Chen +3 more
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Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation
Nature Cell Biology, 2018 N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate.
Huilin Huang +29 more
semanticscholar +1 more source