Results 11 to 20 of about 15,259 (196)

Predicting translation initiation rates for designing synthetic biology [PDF]

Frontiers in Bioengineering and Biotechnology, 2014
In synthetic biology, precise control over protein expression is required in order to construct functional biological systems. A core principle of the synthetic biology approach is model-guided design and, based on biological understanding of the process,
Benjamin eReeve, Benjamin eReeve, Thomas eHargest, Charlie eGilbert, Tom eEllis, Tom eEllis   +5 more
doaj   +2 more sources

Challenges in observing transcription–translation for bottom-up synthetic biology

QRB Discovery
Synthetic biology aims to create a viable synthetic cell. However, to achieve this goal, it is essential first to gain a profound understanding of the cellular systems used to build that cell, how to reconstitute those systems in the compartments, and ...
Vadim G. Bogatyr, Gijs J. L. Wuite
doaj   +2 more sources

Increased sucrose levels mediate selective mRNA translation in Arabidopsis [PDF]

, 2014
Background: Protein synthesis is a highly energy demanding process and is regulated according to cellular energy levels. Light and sugar availability affect mRNA translation in plant cells but the specific roles of these factors remain unclear.
Hanson, Johannes, Smeekens, Sjef, Sub Theoretical Biology & Bioinformatics, Gamm, Magdalena, Peviani, Alessia, Molecular Plant Physiology, Sub Molecular Plant Physiology, Sub Bioinformatics, Honsel, Anne, Honsel, A., Snel, Berend, Honsel, Anne,, Theoretical Biology and Bioinformatics, Hanson, Johannes,   +13 more
core   +1 more source

Ribosome profiling enhances understanding of mycobacterial translation [PDF]

, 2022
A recent addition to the -omics toolkit, ribosome profiling, enables researchers to gain insight into the process and regulation of translation by mapping fragments of mRNA protected from nuclease digestion by ribosome binding. In this review, we discuss
Sawyer, E.B., Cortes, T.
core   +1 more source

The emerging role of RNA modifications in the regulation of mRNA stability

Experimental and Molecular Medicine, 2020
Gene activity: the significance of RNA modification Messenger RNA molecules play their key role in directing the manufacture of proteins via translating the genetic information in DNA.
Sung Ho Boo, Yoon Ki Kim
doaj   +1 more source

Novel capsid binder and PI4KIIIbeta inhibitors for EV-A71 replication inhibition

Scientific Reports, 2021
The Hand, Foot and Mouth Disease (HFMD) is a highly contagious viral illness generally manifests as a mild disease in young children and immunocompromised adults.
Yong Wah Tan, Wan Keat Yam, Rachel Jia Wen Kooi, Jacob Westman, Gustav Arbrandt, Justin Jang Hann Chu   +5 more
doaj   +1 more source

A Comprehensive, Quantitative, and Genome-Wide Model of Translation [PDF]

, 2010
Translation is still poorly characterised at the level of individual proteins and its role in regulation of gene expression has been constantly underestimated.
Piotr Zielenkiewicz, Siwiak, Marlena, Marlena Siwiak, Zielenkiewicz, Piotr   +3 more
core   +1 more source

A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies

Journal of Biomedical Science, 2022
The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis, presenting a broad range of challenges. To help address some of the main problems, the scientific community has designed vaccines, diagnostic tools and therapeutics ...
Monika Kumari, Ruei-Min Lu, Mu-Chun Li, Jhih-Liang Huang, Fu-Fei Hsu, Shih-Han Ko, Feng-Yi Ke, Shih-Chieh Su, Kang-Hao Liang, Joyce Pei-Yi Yuan, Hsiao-Ling Chiang, Cheng-Pu Sun, I.-Jung Lee, Wen-Shan Li, Hsing-Pang Hsieh, Mi-Hua Tao, Han-Chung Wu   +16 more
doaj   +1 more source

Teleworking and collaborative work environments in translation training [PDF]

, 2009
The professional translation work is highly influenced by new communication opportunities, reason why teleworking must occupy its rightful place in translator training at tertiary level.
Muñoz-Martín, Ricardo, Castro-Prieto, María Rosa, Olvera-Lobo, María-Dolores, Robinson, Bryan, Murillo-Melero, Miguel, Conde-Ruano, Tomás, Olvera-Lobo, María Dolores, Senso, Jose A., Quero-Gervilla, Enrique, Muñoz-Raya, Eva   +9 more
core   +1 more source

Translation initiation consistency between in vivo and in vitro bacterial protein expression systems

Frontiers in Bioengineering and Biotechnology, 2023
Strict on-demand control of protein synthesis is a crucial aspect of synthetic biology. The 5′-terminal untranslated region (5′-UTR) is an essential bacterial genetic element that can be designed for the regulation of translation initiation.
Jiaojiao Li, Jiaojiao Li, Peixian Li, Peixian Li, Qian Liu, Qian Liu, Jinjin Li, Jinjin Li, Hao Qi, Hao Qi, Hao Qi   +10 more
doaj   +1 more source