Results 11 to 20 of about 444,056 (268)
Frontiers in Bioengineering and Biotechnology, 2022 Cell-free biology is increasingly utilized for engineering biological systems, incorporating novel functionality, and circumventing many of the complications associated with cells. The central dogma describes the information flow in biology consisting of
Ragunathan Bava Ganesh +1 more
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Beyond Arabidopsis. Translational Biology Meets Evolutionary Developmental Biology [PDF]
Plant Physiology, 2004 Abstract Developmental processes shape plant morphologies, which constitute important adaptive traits selected for during evolution. Identifying the genes that act in developmental pathways and determining how they are modified during evolution is the focus of the field of evolutionary developmental biology, or evo-devo.
Vivian F, Irish, Philip N, Benfey
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eIF2B-capturing viral protein NSs suppresses the integrated stress response
Nature Communications, 2021 Here the authors show that a viral protein interferes with the binding of phosphorylated eIF2 to eIF2B, thereby suppressing the host integrated stress response (ISR). This suppression of the ISR abrogates translational changes of the host and ameliorates
Kazuhiro Kashiwagi +10 more
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Imaging Atherosclerotic Plaque Calcification: Translating Biology [PDF]
Current Atherosclerosis Reports, 2016 Calcification of atherosclerotic lesions was long thought to be an age - related, passive process, but increasingly data has revealed that atherosclerotic calcification is a more active process, involving complex signaling pathways and bone-like genetic programs.
Grant, Bailey +2 more
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The emerging role of RNA modifications in the regulation of mRNA stability
Experimental and Molecular Medicine, 2020 Gene activity: the significance of RNA modification Messenger RNA molecules play their key role in directing the manufacture of proteins via translating the genetic information in DNA.
Sung Ho Boo, Yoon Ki Kim
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Novel capsid binder and PI4KIIIbeta inhibitors for EV-A71 replication inhibition
Scientific Reports, 2021 The Hand, Foot and Mouth Disease (HFMD) is a highly contagious viral illness generally manifests as a mild disease in young children and immunocompromised adults.
Yong Wah Tan +5 more
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Journal of Biomedical Science, 2022 The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis, presenting a broad range of challenges. To help address some of the main problems, the scientific community has designed vaccines, diagnostic tools and therapeutics ...
Monika Kumari +16 more
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The Elements of Translational Chemical Biology [PDF]
Cell Chemical Biology, 2018 A causal relationship between target activity modulation by small molecules and phenotypic consequence is the cornerstone of chemical biology and drug discovery. Here we articulate elements of translational chemical biology, as guideposts to ensure the appropriate use of chemical probes and the conclusions drawn from cellular studies with these ...
Robert A, Copeland +1 more
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Translational Systems Biology of Inflammation
PLoS Computational Biology, 2008 Inflammation is a complex, multi-scale biologic response to stress that is also required for repair and regeneration after injury. Despite the repository of detailed data about the cellular and molecular processes involved in inflammation, including some understanding of its pathophysiology, little progress has been made in treating the severe ...
Vodovotz, Y +4 more
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“Translational” Legume Biology. Models to Crops [PDF]
Plant Physiology, 2005 The last twenty years have been a period of rapid advance in our understanding of plant biology, metabolism, and genomics. In large part, these advances were facilitated by adoption of plant models, the first and most important being Arabidopsis thaliana.
Gary, Stacey, Kate, VandenBosch
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