Results 31 to 40 of about 15,259 (196)

tRNA Thiolation Links Translation to Stress Responses in Saccharomyces cerevisiae [PDF]

, 2014
Although tRNA modifications have been well catalogued, the precise functions of many modifications and their roles in mediating gene expression are still being elucidated.
Ploegh, Hidde, Damon, Jadyn Rose, Pincus, David   +2 more
core   +1 more source

Building the UK's industrial base in engineering biology

Engineering Biology, 2021
The paper describes the strategy and components that have been put in place to build the UK's research and industrial base in Engineering Biology. The initial section of the paper provides a brief historical overview of the development of the field in ...
Richard I. Kitney
doaj   +1 more source

Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan [PDF]

, 2015
Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is unclear.
Wilson, Iain B H, Mohr, Thomas, Mattanovich, Diethard, Breitenbach, Michael, Linder, Angela, Karl, Thomas, Amring, Manuela, Wilson, Iain B.H., Grillari-Voglauer, Regina, Polacek, Norbert, Angerer, Tina B., Rinnerthaler, Mark, Angerer, Tina B, Pircher, Andreas, Schosserer, Markus, Grillari, Johannes, Sharma, Sunny, Minois, Nadege, Breitenbach-Koller, Hannelore, Entian, Karl-Dieter, Kriegner, Albert, Steiger, Matthias, Breitenbach-Koller, Lore, Pfeifenberger, Sigrid, Dellago, Hanna, Calle-Perez, Alfonso, Brandl, Clemens, Weinhäusel, Andreas, Harreither, Eva, Kos, Martin, Sonntagbauer, Markus, Gerstl, Matthias Peter   +31 more
core   +1 more source

Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex

Nature Communications, 2017
Misfolded polypeptide aggregates are actively transported to aggresomes, where they are degraded through aggrephagy. Here the authors show that these aggregates are selectively recognized by the CTIF–eEF1A1–DCTN1 (CED) complex and transported to ...
Joori Park, Yeonkyoung Park, Incheol Ryu, Mi-Hyun Choi, Hyo Jin Lee, Nara Oh, Kyutae Kim, Kyoung Mi Kim, Junho Choe, Cheolju Lee, Ja-Hyun Baik, Yoon Ki Kim   +11 more
doaj   +1 more source

Inhibition of TPL2 by interferon-α suppresses bladder cancer through activation of PDE4D

Journal of Experimental & Clinical Cancer Research, 2018
Background Drugs that inhibit the MEK/ERK pathway have therapeutic benefit in bladder cancer treatment but responses vary with patients, for reasons that are still not very clear.
Zhe Qiang, Zong-yuan Zhou, Ting Peng, Pu-zi Jiang, Nan Shi, Emmanuel Mfotie Njoya, Bahtigul Azimova, Wan-li Liu, Wei-hua Chen, Guo-lin Zhang, Fei Wang   +10 more
doaj   +1 more source

Correction: Wang et al. A VLP-Based Vaccine Displaying HBHA and MTP Antigens of Mycobacterium tuberculosis Induces Potentially Protective Immune Responses in M. tuberculosis H37Ra Infected Mice. Vaccines 2023, 11, 941

Vaccines, 2023
Concerns were brought to the attention of the journal’s editorial office after the paper was published [...]
Juan Wang, Tao Xie, Inayat Ullah, Youjun Mi, Xiaoping Li, Yang Gong, Pu He, Yuqi Liu, Fei Li, Jixi Li, Zengjun Lu, Bingdong Zhu   +11 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Analysing GCN4 Translational Control in Yeast by Stochastic Chemical Kinetics Modelling and Simulation [PDF]

, 2011
Peer ...
You, Tao, Ian Stansfield, Romano, M Carmen, Alistair JP Brown, Coghill, George MacLeod, George M Coghill, M Carmen Romano, Stansfield, Ian, Brown, Alistair James Petersen, Tao You   +9 more
core   +1 more source

The Origin of Translation: Bridging the Nucleotides and Peptides

, 2022
Extant biology uses RNA to record genetic information and proteins to execute biochemical functions. Nucleotides are translated into amino acids via transfer RNA in the central dogma.
Xuyuan Guo, Meng Su
core   +1 more source

Technological advancements in antibody-based therapeutics for treatment of diseases

Journal of Biomedical Science
Monoclonal antibodies (mAbs) represent a major class of therapeutics with widespread clinical applications in oncology, immunology, hematology, neurology and infectious disease.
Ruei-Min Lu, Hsiao-Ling Chiang, Joyce Pei‑Yi Yuan, Hsiu-Hua Wang, Chi-Yung Chen, Sushree Shankar Panda, Kang-Hao Liang, Hung-Pin Peng, Shih-Han Ko, Hung-Ju Hsu, Monika Kumari, Yi-Jen Su, Yi-Ting Tse, Nai-Lin Chou, Han-Chung Wu   +14 more
doaj   +1 more source