Results 21 to 30 of about 444,056 (268)

Progeria: Translational insights from cell biology [PDF]

Journal of Cell Biology, 2012
Cell biologists love to think outside the box, pursuing many surprising twists and unexpected turns in their quest to unravel the mysteries of how cells work. But can cell biologists think outside the bench? We are certain that they can, and clearly some already do.
Gordon, Leslie, Cao, Kan, Collins, Francis S.   +2 more
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Translation initiation consistency between in vivo and in vitro bacterial protein expression systems

Frontiers in Bioengineering and Biotechnology, 2023
Strict on-demand control of protein synthesis is a crucial aspect of synthetic biology. The 5′-terminal untranslated region (5′-UTR) is an essential bacterial genetic element that can be designed for the regulation of translation initiation.
Jiaojiao Li, Jiaojiao Li, Peixian Li, Peixian Li, Qian Liu, Qian Liu, Jinjin Li, Jinjin Li, Hao Qi, Hao Qi, Hao Qi   +10 more
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Natural variability of Kozak sequences correlates with function in a zebrafish model. [PDF]

PLoS ONE, 2014
In eukaryotes, targeting the small ribosomal subunit to the mRNA transcript requires a Kozak sequence at the translation initiation site. Despite the critical importance of the Kozak sequence to regulation of gene expression, there have been no ...
Steven J Grzegorski, Estelle F Chiari, Amy Robbins, Phillip E Kish, Alon Kahana   +4 more
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Predicting translation initiation rates for designing synthetic biology

Frontiers in Bioengineering and Biotechnology, 2014
In synthetic biology, precise control over protein expression is required in order to construct functional biological systems. A core principle of the synthetic biology approach is model-guided design and, based on biological understanding of the process,
Benjamin eReeve, Benjamin eReeve, Thomas eHargest, Charlie eGilbert, Tom eEllis, Tom eEllis   +5 more
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Translational systems biology and voice pathophysiology [PDF]

The Laryngoscope, 2009
AbstractObjectives/Hypothesis:Personalized medicine has been called upon to tailor healthcare to an individual's needs. Evidence‐based medicine (EBM) has advocated using randomized clinical trials with large populations to evaluate treatment effects. However, due to large variations across patients, the results are likely not to apply to an individual ...
Nicole Y K, Li, Katherine Verdolini, Abbott, Clark, Rosen, Gary, An, Patricia A, Hebda, Yoram, Vodovotz   +5 more
openaire   +2 more sources

A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants

Journal of Biomedical Science, 2022
Background With the continuous emergence of new SARS-CoV-2 variants that feature increased transmission and immune escape, there is an urgent demand for a better vaccine design that will provide broader neutralizing efficacy.
I-Jung Lee, Cheng-Pu Sun, Ping-Yi Wu, Yu-Hua Lan, I-Hsuan Wang, Wen-Chun Liu, Joyce Pei-Yi Yuan, Yu-Wei Chang, Sheng-Che Tseng, Szu-I Tsung, Yu-Chi Chou, Monika Kumari, Yin-Shiou Lin, Hui-Feng Chen, Tsung-Yen Chen, Chih-Chao Lin, Chi-Wen Chiu, Chung-Hsuan Hsieh, Cheng-Ying Chuang, Chao-Min Cheng, Hsiu-Ting Lin, Wan-Yu Chen, Fu-Fei Hsu, Ming-Hsiang Hong, Chun-Che Liao, Chih-Shin Chang, Jian-Jong Liang, Hsiu-Hua Ma, Ming-Tsai Chiang, Hsin-Ni Liao, Hui-Ying Ko, Liang-Yu Chen, Yi-An Ko, Pei-Yu Yu, Tzu-Jing Yang, Po-Cheng Chiang, Shang-Te Hsu, Yi-Ling Lin, Chong-Chou Lee, Han-Chung Wu, Mi-Hua Tao   +40 more
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The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases

Molecular Therapy: Nucleic Acids, 2021
YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms,
Zuyao Chen, Xiaolin Zhong, Min Xia, Jing Zhong   +3 more
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Optimizing the Boosting Schedule of Subunit Vaccines Consisting of BCG and “Non-BCG” Antigens to Induce Long-Term Immune Memory

Frontiers in Immunology, 2022
Boosting Bacillus Calmette-Guérin (BCG) with subunit vaccine is expected to induce long-term protection against tuberculosis (TB). However, it is urgently needed to optimize the boosting schedule of subunit vaccines, which consists of antigens from or ...
Wei Lv, Pu He, Yanlin Ma, Daquan Tan, Fei Li, Tao Xie, Jiangyuan Han, Juan Wang, Youjun Mi, Youjun Mi, Hongxia Niu, Bingdong Zhu, Bingdong Zhu   +12 more
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Slicing Into Human Translational Cardiovascular Biology

JACC: Basic to Translational Science, 2016
The heart failure literature is filled with a growing body of research that has identified an array of signaling pathways, transcription factors, noncoding ribonucleic acids (micro- and long noncoding ribonucleic acids), and genetic variants that are associated with either the presence and ...
Kory J. Lavine, MD, PhD, Joel D. Schilling, MD, PhD   +1 more
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In Vivo Translatome Profiling in Spinal Muscular Atrophy Reveals a Role for SMN Protein in Ribosome Biology

Cell Reports, 2017
Summary: Genetic alterations impacting ubiquitously expressed proteins involved in RNA metabolism often result in neurodegenerative conditions, with increasing evidence suggesting that translation defects can contribute to disease.
Paola Bernabò, Toma Tebaldi, Ewout J.N. Groen, Fiona M. Lane, Elena Perenthaler, Francesca Mattedi, Helen J. Newbery, Haiyan Zhou, Paola Zuccotti, Valentina Potrich, Hannah K. Shorrock, Francesco Muntoni, Alessandro Quattrone, Thomas H. Gillingwater, Gabriella Viero   +14 more
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