Results 21 to 30 of about 15,259 (196)

Specialized Yeast Ribosomes: A Customized Tool for Selective mRNA Translation [PDF]

, 2013
Evidence is now accumulating that sub-populations of ribosomes - so-called specialized ribosomes - can favour the translation of subsets of mRNAs. Here we use a large collection of diploid yeast strains, each deficient in one or other copy of the set of ...
Klausegger, Alfred, Brandl Clemens, Lore Breitenbach-Koller, Clemens Br, Bjoern Wimmer (431586), Mick F, Wimmer, Bjoern, Johann W. Bauer (431583), Manuela Weber, Clemens Brandl, Tuite Mick F., Breitenbach-Koller, Hannelore, Klausegger Alfred, Manuela Weber (431587), Johann W. Bauer, Bauer Johann W., Breitenbach-Koller, Lore, Haubenreisser Olaf, Preiss, Thomas, Breitenbach-Koller Lore, Wimmer Bjoern, Helmut Hintner, Michael Breitenbach, Olaf Haubenreisser (431585), Hintner Helmut, Breitenbach, Michael, Mick F Tuite, Alfred Klausegger, Karl Thomas, Weber Manuela, Karl, Thomas, Hintner, Helmut, Bjoern Wimmer, Haar, Thomas Von der, Haubenreisser, Olaf, von der Haar Tobias, Clemens Brandl (431584), Bauer, Johann W., Johann W Bauer, Breitenbach Michael, Thomas Karl, Mick F. Tuite (266570), Lore Breitenbach-Koller (431591), Michael Breitenbach (46789), Bauer, Johann, Tuite, Mick F., von der Haar, Tobias, Olaf Haubenreisser, Helmut Hintner (431590), Brandl, Clemens, Tobias von der Haar, Tobias von der Haar (80575), Alfred Klausegger (431589), Thomas Karl (431588), Weber, Manuela   +54 more
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Natural variability of Kozak sequences correlates with function in a zebrafish model. [PDF]

PLoS ONE, 2014
In eukaryotes, targeting the small ribosomal subunit to the mRNA transcript requires a Kozak sequence at the translation initiation site. Despite the critical importance of the Kozak sequence to regulation of gene expression, there have been no ...
Steven J Grzegorski, Estelle F Chiari, Amy Robbins, Phillip E Kish, Alon Kahana   +4 more
doaj   +1 more source

The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases

Molecular Therapy: Nucleic Acids, 2021
YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms,
Zuyao Chen, Xiaolin Zhong, Min Xia, Jing Zhong   +3 more
doaj   +1 more source

Endoplasmic reticulum : shape and function in stress translation [PDF]

, 2014
The endoplasmic reticulum (ER) is a very versatile organelle. Besides its major role as the gateway to the secretory pathway the ER is central to adaptation against abiotic and biotic stress.
Stephen H. Howell, Schäfer, Patrick, Patrick Schafer, Howell, Stephen H., Frigerio, Lorenzo, Patrick eSchäfer, Lorenzo Frigerio, Brandizzi, Federica, Stephen H Howell, Federica Brandizzi, Patrick Schäfer, Federica eBrandizzi, Lorenzo eFrigerio   +12 more
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Optimizing the Boosting Schedule of Subunit Vaccines Consisting of BCG and “Non-BCG” Antigens to Induce Long-Term Immune Memory

Frontiers in Immunology, 2022
Boosting Bacillus Calmette-Guérin (BCG) with subunit vaccine is expected to induce long-term protection against tuberculosis (TB). However, it is urgently needed to optimize the boosting schedule of subunit vaccines, which consists of antigens from or ...
Wei Lv, Pu He, Yanlin Ma, Daquan Tan, Fei Li, Tao Xie, Jiangyuan Han, Juan Wang, Youjun Mi, Youjun Mi, Hongxia Niu, Bingdong Zhu, Bingdong Zhu   +12 more
doaj   +1 more source

Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail [PDF]

, 2015
A phylogenetically conserved RNA structure within the NS5B coding region of hepatitis C virus functions as a cis-replicating element (CRE). Integrity of this CRE, designated SL9266 (alternatively 5BSL3.2), is critical for genome replication. SL9266 forms
Struthers, M, Tuplin, AK, Tuplin, Andrew, Bentley, K, Struthers, Madeleine, Cook, J, Cook, Jonathan, Evans, DJ, Evans, David J., Struthers, Madeline, Bentley, Kirsten, Cook, Jonathan P.   +11 more
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In Vivo Translatome Profiling in Spinal Muscular Atrophy Reveals a Role for SMN Protein in Ribosome Biology

Cell Reports, 2017
Summary: Genetic alterations impacting ubiquitously expressed proteins involved in RNA metabolism often result in neurodegenerative conditions, with increasing evidence suggesting that translation defects can contribute to disease.
Paola Bernabò, Toma Tebaldi, Ewout J.N. Groen, Fiona M. Lane, Elena Perenthaler, Francesca Mattedi, Helen J. Newbery, Haiyan Zhou, Paola Zuccotti, Valentina Potrich, Hannah K. Shorrock, Francesco Muntoni, Alessandro Quattrone, Thomas H. Gillingwater, Gabriella Viero   +14 more
doaj   +1 more source

A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants

Journal of Biomedical Science, 2022
Background With the continuous emergence of new SARS-CoV-2 variants that feature increased transmission and immune escape, there is an urgent demand for a better vaccine design that will provide broader neutralizing efficacy.
I-Jung Lee, Cheng-Pu Sun, Ping-Yi Wu, Yu-Hua Lan, I-Hsuan Wang, Wen-Chun Liu, Joyce Pei-Yi Yuan, Yu-Wei Chang, Sheng-Che Tseng, Szu-I Tsung, Yu-Chi Chou, Monika Kumari, Yin-Shiou Lin, Hui-Feng Chen, Tsung-Yen Chen, Chih-Chao Lin, Chi-Wen Chiu, Chung-Hsuan Hsieh, Cheng-Ying Chuang, Chao-Min Cheng, Hsiu-Ting Lin, Wan-Yu Chen, Fu-Fei Hsu, Ming-Hsiang Hong, Chun-Che Liao, Chih-Shin Chang, Jian-Jong Liang, Hsiu-Hua Ma, Ming-Tsai Chiang, Hsin-Ni Liao, Hui-Ying Ko, Liang-Yu Chen, Yi-An Ko, Pei-Yu Yu, Tzu-Jing Yang, Po-Cheng Chiang, Shang-Te Hsu, Yi-Ling Lin, Chong-Chou Lee, Han-Chung Wu, Mi-Hua Tao   +40 more
doaj   +1 more source

New Perspectives on Reverse Translation: Brief History and Updates

Universitas Scientiarum, 2023
Since the 1950s, reverse translation has been an enigmatic part of Crick’s central dogma of molecular biology. It might be described as the possibility to back-translate information from proteins to nucleic acids (or codons).
Adhityo Wicaksono, Viol Dhea Kharisma, Arli Aditya Parikesit   +2 more
doaj   +1 more source

Molecular Biology

, 2023
This course covers a detailed analysis of the biochemical mechanisms that control the maintenance, expression, and evolution of prokaryotic and eukaryotic genomes. The topics covered in lectures and readings of relevant literature include gene regulation,
Faculty, Biology Department
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