Results 41 to 50 of about 2,436,936 (150)

LifeMap Discovery™: the embryonic development, stem cells, and regenerative medicine research portal. [PDF]

PLoS ONE, 2013
LifeMap Discovery™ provides investigators with an integrated database of embryonic development, stem cell biology and regenerative medicine. The hand-curated reconstruction of cell ontology with stem cell biology; including molecular, cellular ...
Ron Edgar, Yaron Mazor, Ariel Rinon, Jacob Blumenthal, Yaron Golan, Ella Buzhor, Idit Livnat, Shani Ben-Ari, Iris Lieder, Alina Shitrit, Yaron Gilboa, Ahmi Ben-Yehudah, Osnat Edri, Netta Shraga, Yoel Bogoch, Lucy Leshansky, Shlomi Aharoni, Michael D West, David Warshawsky, Ronit Shtrichman   +19 more
doaj   +1 more source

Severe persistent mycobacteria antigen stimulation causes lymphopenia through impairing hematopoiesis

Frontiers in Cellular and Infection Microbiology, 2023
Miliary tubersculosis (TB), an acute systemic blood disseminated tuberculosis mainly caused by Mycobacterium tuberculosis (M. tuberculosis), can cause signs of lymphopenia in clinical patients.
Fei Li, Yanlin Ma, Xiaoping Li, Dan Zhang, Jiangyuan Han, Daquan Tan, Youjun Mi, Youjun Mi, Xiaojuan Yang, Xiaojuan Yang, Juan Wang, Bingdong Zhu, Bingdong Zhu   +12 more
doaj   +1 more source

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

RNA Biology, 2017
HuR influences gene expression programs and hence cellular phenotypes by binding to hundreds of coding and noncoding linear RNAs. However, whether HuR binds to circular RNAs (circRNAs) and impacts on their function is unknown. Here, we have identified en
K. Abdelmohsen, A. Panda, R. Munk, Ioannis Grammatikakis, D. Dudekula, Supriyo De, Jiyoung Kim, J. Noh, Kyoung Mi Kim, J. Martindale, M. Gorospe   +10 more
semanticscholar   +1 more source

Non-coding RNAs secreted by renal cancer include piR_004153 that promotes migration of mesenchymal stromal cells

Cell Communication and Signaling
Background Renal cell cancer (RCC) is the most common and highly malignant subtype of kidney cancer. Mesenchymal stromal cells (MSCs) are components of tumor microenvironment (TME) that influence RCC progression.
Joanna Bogusławska, Małgorzata Grzanka, Piotr Popławski, Weronika Zarychta-Wiśniewska, Anna Burdzinska, Karolina Hanusek, Helena Kossowska, Roksana Iwanicka-Nowicka, Alex Białas, Beata Rybicka, Anna Adamiok-Ostrowska, Joanna Życka-Krzesińska, Marta Koblowska, Leszek Pączek, Agnieszka Piekiełko-Witkowska   +14 more
doaj   +1 more source

Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases

Circulation, 2021
Exosomes are small membrane-bound vesicles of endocytic origin that are actively secreted. The potential of exosomes as effective communicators of biological signaling in myocardial function has previously been investigated, and a recent explosion in ...
S. Sahoo, M. Adamiak, P. Mathiyalagan, Franziska Kenneweg, S. Kafert-Kasting, T. Thum   +5 more
semanticscholar   +1 more source

Polysome Profiling Analysis

Bio-Protocol, 2013
Polysome profiling is a method that allows monitoring of translation activity of mRNAs in cells and tissues. Once each polysome fractions are collected, the translation activity of each mRNA is analyzed using various molecular biology techniques such as ...
Masahiro Morita, Tommy Alain, Ivan Topisirovic, Nahum Sonenberg   +3 more
doaj   +1 more source

Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH

Nature Communications
Ribosome hibernation is a key survival strategy bacteria adopt under environmental stress, where a protein, hibernation promotion factor (HPF), transitorily inactivates the ribosome.
Niraj Kumar, Shivani Sharma, Prem S. Kaushal   +2 more
doaj   +1 more source

mRNA Targeting, Transport and Local Translation in Eukaryotic Cells: From the Classical View to a Diversity of New Concepts

Molecular Biology, 2021
Spatial organization of protein biosynthesis in the eukaryotic cell has been studied for more than fifty years, thus many facts have already been included in textbooks. According to the classical view, mRNA transcripts encoding secreted and transmembrane
K. A. Lashkevich, S. Dmitriev
semanticscholar   +1 more source

Structural basis for Gemin5 decamer-mediated mRNA binding

Nature Communications, 2022
Structural biology, complemented by biochemistry experiments and RNA-binding assays show that the Gemin5 C-terminal region adopts a decamer architecture. Gemin5 decamerization is essential for its role in regulating mRNA translation.
Qiong Guo, Shidong Zhao, Rosario Francisco-Velilla, Jiahai Zhang, Azman Embarc-Buh, Salvador Abellan, Mengqi Lv, Peiping Tang, Qingguo Gong, Huaizong Shen, Linfeng Sun, Xuebiao Yao, Jinrong Min, Yunyu Shi, Encarnacion Martínez-Salas, Kaiming Zhang, Chao Xu   +16 more
doaj   +1 more source

The new survivors and a new era for trauma research. [PDF]

PLoS Medicine, 2017
Karim Brohi and Martin Schreiber, Guest Editors of the Special Issue on Trauma, describe a new era in exploration of the biology of injury response and translation of new opportunities into clinical practice.
Karim Brohi, Martin Schreiber
doaj   +1 more source