Results 41 to 50 of about 2,536,108 (315)
Vaccines, 2023 Heparin-binding hemagglutinin (HBHA) and M. tuberculosis pili (MTP) are important antigens on the surface of Mycobacterium tuberculosis. To display these antigens effectively, the fusion protein HBHA-MTP with a molecular weight of 20 kD (L20) was ...
Juan Wang +11 more
doaj +1 more source
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Technological advancements in antibody-based therapeutics for treatment of diseases
Journal of Biomedical ScienceMonoclonal antibodies (mAbs) represent a major class of therapeutics with widespread clinical applications in oncology, immunology, hematology, neurology and infectious disease.
Ruei-Min Lu +14 more
doaj +1 more source
On the Ribosomal Density that Maximizes Protein Translation Rate. [PDF]
PLoS ONE, 2016 During mRNA translation, several ribosomes attach to the same mRNA molecule simultaneously translating it into a protein. This pipelining increases the protein translation rate.
Yoram Zarai +2 more
doaj +1 more source
A working model for cytoplasmic assembly of H/ACA snoRNPs
FEBS Letters, EarlyView.Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source
Synthetic biology in the UK – An outline of plans and progress
Synthetic and Systems Biotechnology, 2016 Synthetic biology is capable of delivering new solutions to key challenges spanning the bioeconomy, both nationally and internationally. Recognising this significant potential and the associated need to facilitate its translation and commercialisation ...
L.J. Clarke, R.I. Kitney
doaj +1 more source
Novel and unscrutinized immune entities of the zebrafish gut
FEBS Letters, EarlyView.Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
wiley +1 more source
Caloric Restriction Induces MicroRNAs to Improve Mitochondrial Proteostasis
iScience, 2019 Summary: Both caloric restriction (CR) and mitochondrial proteostasis are linked to longevity, but how CR maintains mitochondrial proteostasis in mammals remains elusive. MicroRNAs (miRNAs) are well known for gene silencing in cytoplasm and have recently
Ran Zhang +17 more
doaj +1 more source
LifeMap Discovery™: the embryonic development, stem cells, and regenerative medicine research portal. [PDF]
PLoS ONE, 2013 LifeMap Discovery™ provides investigators with an integrated database of embryonic development, stem cell biology and regenerative medicine. The hand-curated reconstruction of cell ontology with stem cell biology; including molecular, cellular ...
Ron Edgar +19 more
doaj +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source