Results 41 to 50 of about 3,070,291 (402)

The Elements of Translational Chemical Biology [PDF]

Cell Chemical Biology, 2018
A causal relationship between target activity modulation by small molecules and phenotypic consequence is the cornerstone of chemical biology and drug discovery. Here we articulate elements of translational chemical biology, as guideposts to ensure the appropriate use of chemical probes and the conclusions drawn from cellular studies with these ...
Robert A, Copeland, P Ann, Boriack-Sjodin   +1 more
openaire   +2 more sources

Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation

Stem cell research & therapeutics, 2017
Adipose/fat tissue provides an abundant source of stromal vascular fraction (SVF) cells for immediate administration and can also give rise to a substantial number of cultured, multipotent adipose-derived stromal cells (ADSCs).
Pablo Bora, A. Majumdar
semanticscholar   +1 more source

Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. [PDF]

, 2013
The initiation of protein synthesis plays an essential regulatory role in human biology. At the center of the initiation pathway, the 13-subunit eukaryotic translation initiation factor 3 (eIF3) controls access of other initiation factors and mRNA to the
Arias-Palomo, Ernesto, Cate, Jamie HD, Doudna, Jennifer A, Mortimer, Stefanie A, Nogales, Eva, Querol-Audí, Jordi, Sun, Chaomin   +6 more
core   +1 more source

Translational Systems Biology of Inflammation

PLoS Computational Biology, 2008
Inflammation is a complex, multi-scale biologic response to stress that is also required for repair and regeneration after injury. Despite the repository of detailed data about the cellular and molecular processes involved in inflammation, including some understanding of its pathophysiology, little progress has been made in treating the severe ...
Vodovotz, Y, Csete, M, Bartels, J, Chang, S, An, G   +4 more
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“Translational” Legume Biology. Models to Crops [PDF]

Plant Physiology, 2005
The last twenty years have been a period of rapid advance in our understanding of plant biology, metabolism, and genomics. In large part, these advances were facilitated by adoption of plant models, the first and most important being Arabidopsis thaliana.
Gary, Stacey, Kate, VandenBosch
openaire   +2 more sources

The genetics of obesity: from discovery to biology

Nature reviews genetics, 2021
The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people’s health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases.
R. Loos, G. Yeo
semanticscholar   +1 more source

Progeria: Translational insights from cell biology [PDF]

Journal of Cell Biology, 2012
Cell biologists love to think outside the box, pursuing many surprising twists and unexpected turns in their quest to unravel the mysteries of how cells work. But can cell biologists think outside the bench? We are certain that they can, and clearly some already do.
Gordon, Leslie, Cao, Kan, Collins, Francis S.   +2 more
openaire   +3 more sources

Translation initiation consistency between in vivo and in vitro bacterial protein expression systems

Frontiers in Bioengineering and Biotechnology, 2023
Strict on-demand control of protein synthesis is a crucial aspect of synthetic biology. The 5′-terminal untranslated region (5′-UTR) is an essential bacterial genetic element that can be designed for the regulation of translation initiation.
Jiaojiao Li, Jiaojiao Li, Peixian Li, Peixian Li, Qian Liu, Qian Liu, Jinjin Li, Jinjin Li, Hao Qi, Hao Qi, Hao Qi   +10 more
doaj   +1 more source

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas [PDF]

, 2018
Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking.
Abdel-Rahman, Mohamed H., Abeshouse, Adam, Adebamowo, Clement, Adebamowo, Sally N., Agnew, Kathy, Ahn, Keunsoo, Ajani, Jaffer A., Akbani, Rehan, Akeredolu, Teniola, Al-Ahmadie, Hikmat, Albert, Monique, Alexopoulou, Iakovina, Ally, Adrian, Alvaro, Domenico, Anderson, Matthew L., Andry, Chris, Angulo Gonzalez, Ana Maria, Antenucci, Anna, Anur, Pavana, Appelbaum, Elizabeth L., Aredes, Natália D., Armenia, Joshua, Arnaout, Angel, Asa, Sylvia L., Auman, J. Todd, Ayer, Donald E., Aymerich, Marta, Aziz, Dina, Bailey, Matthew, Balasundaram, Miruna, Balu, Saianand, Barnett, Gene, Barnholtz-Sloan, Jill S., Barrett, Wendi, Bartlett, John, Bathe, Oliver, Baudin, Eric, Baylin, Stephen, Becker, Karl-Friedrich, Beer, David, Behera, Madhusmita, Behrens, Carmen, Bell, Debra, Bell, Sue, Bellair, Michelle, Bennett, Joseph, Benz, Christopher, Berchuck, Andrew, Berger, Ashton C., Berger, Ashton C., Bergeron, Alain, Berkowitz, Ross, Bernard, Brady, Bernard, Brady, Beroukhim, Rameen, Beuschlein, Felix, Bifulco, Carlo, Bigner, Darell, Birrer, Michael, Birsoy, Kivanc, Bocklage, Therese, Bodenheimer, Tom, Bondaruk, Jolanta, Bootwalla, Moiz S., Borad, Mitesh, Borgia, Jeffrey A., Bossler, Aaron, Botnariuc, Natalia, Boussioutas, Alex, Bowen, Jay, Bowlby, Reanne, Bowman, Rayleen, Bradford, Carol, Bragazzi, Maria Consiglia, Brat, Daniel J., Breggia, Anne, Brewer, Cathy, Brimo, Fadi, Broaddus, Russell, Brooks, Denise, Broom, Bradley M., Broudy, Thomas, Bryce, Alan H., Bubley, Glenn, Bueno, Raphael, Burnette, Andrew, Caesar-Johnson, Samantha J., Calatozzolo, Chiara, Campo, Elias, Campos, Benito, Caraman, Irina, Cardinale, Vincenzo, Carey, Francis, Carey, Thomas, Carlotti, Carlos Gilberto, Carlsen, Rebecca, Carney, Michael, Carpino, Guido, Carroll, Peter R., Carter, Candace, Carvalho, Andre L., Castle, Erik, Castro, Patricia D., Catto, James, Cebulla, Colleen M., Cernat, Mircea, Chabot, John, Chakravarty, Debyani, Chambwe, Nyasha, Chan, June M., Chan, Timothy A., Chandan, Vishal, Chang, Kyle, Chatila, Walid K., Chemencedji, Inga, Chen, Amy, Chen, Chu, Cheng, Feixiong, Cherniack, Andrew D., Cherniack, Andrew D., Chesla, David, Chevalier, Simone, Cheville, John, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Chung, Ki, Cibulskis, Carrie, Clipca, Adrian, Colman, Howard, Cope, Leslie, Copland, John A., Corcoran, Niall, Cordes, Matthew G., Costello, Tony, Cottingham, Sandra, Couce, Marta, Covington, Kyle, Crain, Daniel, Cramer, Daniel, Creaney, Jenette, Creighton, Chad J., Cuppini, Lucia, Curley, Erin, Cuzzubbo, Stefania, Czerniak, Bogdan, Danilova, Ludmila, Davis, Amy, de Bruijn, Ino, de Carvalho, Ana C., de Krijger, Ronald, De Rienzo, Assunta, De Rose, Agostino, Defreitas, Timothy, Delman, Keith, Demchok, John A., Desjardins, Laurence, Devine, Karen, Deyarmin, Brenda, Dhalla, Noreen, Dhanasekaran, Renumathy, Dhankani, Varsha, Dhankani, Varsha, Dhir, Rajiv, Dimeco, Francesco, Ding, Li, Dinh, Huyen, Dinkin, Mikhail, Dipersio, John, Disaia, Philip, Doddapaneni, Harshavardhan, Donehower, Lawrence A., Doruc, Serghei, Dos Santos, Jose Sebastião, Dottino, Peter R., Drake, Bettina, Drummond, Jennifer, Drwiega, Paul, Dubina, Michael, Duell, Rebecca, Duffy, Elizabeth R., Eckman, John, Edenfield, W. Jeffrey, Eijckenboom, Wil, Eisenman, Robert N., Elder, J. Bradley, Engel, Jay, Eschbacher, Jennifer, Esmaeli, Bita, Evason, Kimberley, Facciolo, Francesco, Fan, Cheng, Fan, Huihui, Fantacone-Campbell, J. Leigh, Farnell, Michael, Farver, Carol, Fassnacht, Martin, Fehrenbach, Ashley, Felau, Ina, Feldman, Michael, Feltmate, Colleen, Ferguson, Martin L., Finocchiaro, Gaetano, Flotte, Thomas, Fong, Kwun M., Force, Seth, Forgie, Ian, Frazer, Scott, Fregnani, José H., Fronick, Catrina C., Fujimoto, Junya, Fulop, Jordonna, Fulton, Lucinda A., Fulton, Robert S., Gabra, Hani, Gabriel, Stacey B., Galbraith, Joseph, Gao, Galen F., Gao, Jianjiong, Gardner, Johanna, Gastier-Foster, Julie M., Gaudio, Eugenio, Gehlenborg, Nils, Gerken, Mark, Gershenwald, Jeffrey, Getz, Gad, Ghossein, Ronald, Giama, Nasra, Gibbs, Richard A., Gilbert, Sebastien, Gillis, Ad, Gimenez-Roqueplo, Anne-Paule, Giné, Eva, Giordano, Thomas, Girard, Nicolas, Giuliante, Felice, Glenn, Pat, Glenn, Robert, Godwin, Andrew K., Godwin, Eryn M., Goodman, Marc, Gopalan, Anuradha, Goparaju, Chandra, Gorincioi, Ghenadie, Govindan, Ramaswamy, Graefen, Markus, Grandori, Carla, Grazi, Gianluca, Grizzle, William E., Gross, Benjamin E., Guillermo, Armando López, Guo, Charles, Ha, Gavin, Haddad, Andrea, Hagedorn, Curt H., Hale, Walker, Han, Yi, Hanh, Phan Thi, Hansen, Paul, Harr, Jodi, Hartmann, Arndt, Haydu, Lauren, Hayes, D. Neil, Hayward, Nicholas, Heath, Sharon, Hegde, Apurva M., Heiman, David I., Heins, Zachary J., Henderson, Joel, Hermes, Beth, Hernandez, Brenda, Herold-Mende, Christel, Hersey, Peter, Hess, Julian, Hibshoosh, Hanina, Hilty, Joe, Hinoue, Toshinori, Ho, Thai, Hoadley, Katherine A., Holt, Robert, Hooke, Jeffrey A., Hoon, Dave, Horowitz, Neil, Houck, John, Hovens, Christopher, Hoyle, Alan P., Hu, Hai, Hu, Jianhong, Huland, Hartwig, Hung, Nguyen Phi, Huntsman, David, Hurlin, Peter J., Hutter, Carolyn M., Iacocca, Mary, Ittmann, Michael, Jacobus, Laura, Jakrot, Valerie, Janssen, Klaus-Peter, Jefferys, Stuart R., Jimeno, Antonio, Jones, Corbin D., Jones, Steven J. M., Ju, Zhenlin, Juhl, Hartmut, Jungk, Christin, Junker, Kerstin, Kakavand, Hojabr, Kalkanis, Steven, Kanchi, Rupa S., Kandoth, Cyriac, Kang, Koo Jeong, Karlan, Beth Y., Kasaian, Katayoon, Kasapi, Melpomeni, Kastl, Alison, Kebebew, Electron, Kefford, Richard, Kelley, Robin K., Kemp, Rafael, Kendall, Sara, Kendler, Ady, Kendrick, Michael, Khuri, Fadlo, Kibel, Adam, Kim, Jaegil, Knijnenburg, Theo, Knudson, Michael, Knutson, Tina, Kocher, Jean-Pierre, Kohl, Bernard, Kopp, Karla, Korchina, Viktoriya, Korkut, Anil, Korpershoek, Esther, Korst, Robert, Kovatich, Albert J., Kramer, Roger, Kucherlapati, Melanie H., Kucherlapati, Raju S., Kumar, Bahavna, Kundra, Ritika, Kvecher, Leonid, Kycler, Witold, La, Konnor, Lacombe, Louis, Ladanyi, Marc, Lai, Phillip H., Laird, Peter W., Landen, Charles N., Landrum, Lisa, Lang, James, Larson, Caroline, Latour, Mathieu, Lau, Kevin, Lawrence, Michael S., Lazar, Alexander J., Le, Xuan, Lechan, Ronald, Lee, Darlene, Lee, Jung Il, Lee, Kenneth, Lee, Sandra, Lehman, Norman L., Leinonen, Kalle, Leraas, Kristen M., Levine, Douglas A., Lewis, Lora, Ley, Timothy, Li, Jun, Li, Wei, Liang, Han, Lichtenberg, Tara M., Lin, Pei, Linehan, W. Marston, Ling, Shiyun, Lipp, Eric, Liptay, Michael J., Liu, Jia, Liu, Wenbin, Liu, Xiuping, Liu, Yuexin, Liu, Yuexin, Logothetis, Christopher, Lohavanichbutr, Pawadee, Lolla, Laxmi, Long, Georgina, Longatto-Filho, Adhemar, Looijenga, Leendert, Lu, Yiling, Luketich, James, Luna, Augustin, Lyadov, Vladimir, Ma, Deqin, Ma, Yussanne, Madan, Rashna, Maglinte, Dennis T., Magliocca, Kelly, Maithel, Shishir, Mallery, David, Malykh, Andrei, Mandt, Randy, Manikhas, George, Mann, Graham, Mannel, Robert, Mannelli, Massimo, Mardis, Elaine R., Mariamidze, Armaz, Mariani, Odette, Marino, Mirella, Marks, Jeffrey, Marra, Marco A., Martignetti, John A., Martin, Julie, Mattei, Luca, Mayo, Michael, Mccall, Shannon, Mcgraw, Mary, Mckercher, Ginette, Mclellan, Michael D., Mclendon, Roger, Mcpherson, Christopher, Meier, Sam, Melamed, Jonathan, Meng, Shaowu, Meric-Bernstam, Funda, Merola, Roberta, Mes-Masson, Anne-Marie, Metwalli, Adam R., Meyerson, Matthew, Mieczkowski, Piotr A., Mikkelsen, Tom, Milhem, Mohammed, Miller, Christopher A., Miller, Judy, Miller, Michael, Mills, Gordon B., Mirsaidi, Cyrus, Moiseenko, Fedor, Moncrieff, Marc, Moore, Kathleen, Moore, Richard A., Mora Pinero, Edna M., Moran, Cesar, Morgan, Margaret, Morris, Scott, Morrison, Carl, Morton, Donna, Mose, Lisle E., Moser, Catherine, Moxley, Katherine, Moyer, Jeffey, Mungall, Andrew J., Mungall, Karen, Mura, Sergiu, Mural, Richard J., Murawa, Dawid, Muto, Michael, Muzny, Donna, Myers, Jerome, Nagorney, David, Nair, Praveen, Naresh, Rashi, Naska, Theresa, Nelson, Mark, Ng, Kwok-Shing, Nguyen, Phuong, Nissan, Moriah G., Noble, Michael S., Noss, Ardene, Noushmehr, Houtan, O'Brien, Daniel, O'Neill, Brian Patrick, Ochoa, Angelica, Olabode, Oluwole, Olson, Jeffrey J., Omberg, Larsson, Oosterhuis, Wolter, Ostrom, Quinn T., Owonikoko, Taofeek, Pacak, Karel, Paklina, Oxana, Parfitt, Jeremy, Park, Joong-Won, Parker, Joel S., Pass, Harvey, Patel, Tushar, Paulauskis, Joseph, Pennell, Nathan A., Penny, Robert, Perin, Alessandro, Perou, Amy H., Perou, Charles M., Petersen, Gloria, Peterson, Lisa, Peto, Myron, Phillips, Joanna, Phillips, Sarah M., Phu, Bui Duc, Piché, Alain, Pickens, Alan, Pihl, Todd, Pilarski, Robert, Pinto, Peter A., Pirtac, Maria, Pollo, Bianca, Pool, Mark, Porten, Sima, Postier, Russel, Potapova, Olga, Powers, James, Prados, Michael, Prince, Mark, Que, Florencia, Quinn, Michael, Quintero-Aguilo, Mario, Rabeno, Brenda, Rai, Karan, Ramalingam, Suresh, Ramirez, Nilsa C., Ramondetta, Lois, Rao, Arvind, Rassl, Doris M., Rathmell, W. Kimryn, Raut, Chandrajit P., Raymond, Daniel, Reis, Rui M., Reuter, Victor, Reynolds, Sheila, Reznik, Ed, Rice, David, Richards, William G., Richardson, Anne B., Rintoul, Robert C., Rivera, Michael, Roach, Jeffrey, Roberts, Lewis, Robertson, A. Gordon, Robinson, Bruce, Roggin, Kevin, Roman-Roman, Sergio, Rosenthal, Howard G., Rozek, Laura, Rubin, Mark A., Ryan, Michael, Saad, Fred, Sadeghi, Sara, Saksena, Gordon, Sanchez-Vega, Francisco, Sander, Chris, Sankarankuty, Ajith, Santibanez, Jireh, Sastre, Xavier, Sauter, Guido, Saw, Robyn, Scapulatempo-Neto, Cristovam, Scarpace, Lisa, Schadendorf, Dirk, Schaub, Franz X., Schein, Jacqueline E., Schiffman, Mark, Schilero, Cathy, Schlomm, Thorsten, Schmidt, Heather K., Schmidt, Laura S., Schoenfield, Lynn, Schultz, Nikolaus, Schumacher, Steven E., Scolyer, Richard, Secord, Angeles, Seder, Christopher W., Sekhon, Harman, Senecal, Kelly, Sepulveda, Antonia, Setdikova, Galiya, Sexton, Katherine C., Shabunin, Alexey, Shannon, Kerwin, Sharp, Alexis, Shaw, Reid, Shelley, Carl Simon, Shelton, Candace, Shelton, Troy, Shen, Hui, Sheridan, Robert, Sherman, Mark, Sheth, Margi, Shi, Yan, Shih, Juliann, Shimmel, Kristen, Shin, Dong M., Shinbrot, Eve, Shipman, Cassaundra, Shmulevich, Ilya, Shriver, Craig D., Sica, Gabriel, Sifri, Suzanne, Sigmund, Rita, Signoretti, Sabina, Silveira, Henrique C. S., Simko, Jeffry, Simon, Ronald, Simons, Janae V., Singer, Samuel, Singh, Bhuvanesh, Singh, Rosy, Sipahimalani, Payal, Skelly, Tara, Sloan, Andrew E., Slotta-Huspenina, Julia, Smallridge, Robert, Smith, Jennifer, Smith-McCune, Karen, Smolenski, Kathy, Smyrk, Thomas, Sofia, Heidi J., Soloway, Matthew G., Somiari, Stella, Sood, Anil, Spellman, Paul, Spillane, Andrew, Stancul, Irina, Stanton, Melissa, Staugaitis, Susan M., Steele, Ruth, Stepa, Serghei, Stern, Marc-Henri, Stoehr, Christine, Stoehr, Robert, Stoop, Hans, Stretch, Jonathan, Stuart, Joshua M., Su, Tao, Sumer, S. Onur, Sun, Qiang, Sun, Yichao, Swanson, Patricia, Swisher, Elizabeth, Synott, Maria, Tam, Angela, Tamakawa, Raina, Tamboli, Pheroze, Tan, Donghui, Tang, Yufang, Tarnuzzer, Roy, Taubert, Helge, Tavobilov, Mikhail, Taylor, Barry S., Tcaciuc, Diana, Tennstedt, Pierre, Thiessen, Nina, Thomas, George, Thompson, Eric, Thompson, John, Thompson, R. Houston, Thompson, Timothy, Thorp, Richard, Thorsson, Vesteinn, Tien, Nguyen Viet, Timmers, Henri, Tirapelli, Daniela, Tischler, Arthur, Torbenson, Michael, Trivedi, Mihir, Troncoso, Patricia, Tsao, Anne, Tse, Kane, Tucker, Kelinda, Têtu, Bernard, Unterberg, Andreas, Urba, Walter, Valdivieso, Federico, Van Bang, Nguyen, Van Den Berg, David J., van Kessel, Kim E., Van Meir, Erwin G., Van Tine, Brian, Vandenberg, Scott, Veluvolu, Umadevi, Ventura, Andrea, Vicha, Ales, Vidal, Daniel O., Vocke, Cathy D., Voet, Doug, von Deimling, Andreas, Voronina, Olga, Wach, Sven, Wakely, Paul, Waldmann, Jens, Walker, Joan, Wan, Yunhu, Wang, Jing, Wang, Jioajiao, Wang, Linghua, Wang, Min, Wang, Timothy, Wang, Zhining, Warnick, Ronald, Weinstein, John N., Weisenberger, Daniel J., Wentzensen, Nicolas, Westervelt, Peter, Wheeler, David A., Wilkerson, Matthew D., Williams, Felicia, Wilmott, James, Wilson, Richard K., Wise, Lisa, Wistuba, Ignacio, Wiznerowicz, Maciej, Wolf, Gregory, Wolinsky, Yingli, Wong, Christopher K., Wong, Tina, Worrell, Robert, Wu, Ye, Wullich, Bernd, Xi, Liu, Yang, Hannah, Yang, Ian, Yang, Ju Dong, Yang, Liming, Yau, Christina, Yena, Peggy, Zach, Leigh Anne, Zaren, Howard, Zelinka, Tomas, Zenklusen, Jean C., Zhang, Hailei, Zhang, Hongxin, Zhang, Hongzheng, Zhang, Jiashan (Julia), Zhang, Jiexin, Zhang, Lizhi, Zhang, Wei, Zhang, Xiaoyang, Zhao, Fengmei, Zhao, Wei, Zhou, Wanding, Zmuda, Erik, Zuna, Rosemary, Zwarthoff, Ellen C.   +740 more
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Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation

Nature Cell Biology, 2018
N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate.
Huilin Huang, Hengyou Weng, Wen-Ju Sun, Xi Qin, Hailing Shi, Huizhe Wu, B. Zhao, Ana Mesquita, Chang Liu, Celvie L. Yuan, Yueh-Chiang Hu, S. Hüttelmaier, Jennifer Skibbe, R. Su, Xiaolan Deng, Lei Dong, Miao Sun, Chenying Li, S. Nachtergaele, Yungui Wang, Chao Hu, Kyle Ferchen, K. Greis, Xi Jiang, M. Wei, Lianghu Qu, J. Guan, Chuan He, Jianhua Yang, Jianjun Chen   +29 more
semanticscholar   +1 more source