Results 51 to 60 of about 2,436,936 (150)

The scanning model for translation: an update

Journal of Cell Biology, 1989
The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation.
M. Kozak
semanticscholar   +1 more source

The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases

Molecular Therapy: Nucleic Acids, 2021
YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms,
Zuyao Chen, Xiaolin Zhong, Min Xia, Jing Zhong   +3 more
doaj  

The expanding incretin universe: from basic biology to clinical translation

Diabetologia, 2023
D. Drucker, J. Holst
semanticscholar   +1 more source

HIV transmission biology: translation for HIV prevention.

AIDS (London), 2015
Rigorous testing of new HIV-prevention strategies is a time-consuming and expensive undertaking. Thus, making well informed decisions on which candidate-prevention approaches are most likely to provide the most benefit is critical to appropriately ...
K. Ronen, Amit Sharma, J. Overbaugh
semanticscholar   +1 more source

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation

Journal of Hematology & Oncology, 2020
Synthetic lethality is a lethal phenomenon in which the occurrence of a single genetic event is tolerable for cell survival, whereas the co-occurrence of multiple genetic events results in cell death. The main obstacle for synthetic lethality lies in the
Win Topatana, Sarun Juengpanich, Shijie Li, Jiasheng Cao, Jiahao Hu, Jiyoung Lee, Kenneth Suliyanto, D. Ma, Bin Zhang, Mingyu Chen, Xiujun Cai   +10 more
semanticscholar   +1 more source

Pregnant women’s views on how to promote the use of a decision aid for Down syndrome prenatal screening: a theory-informed qualitative study

BMC Health Services Research, 2018
Background For pregnant women and their partners, the decision to undergo Down syndrome prenatal screening is difficult. Patient decision aids (PtDA) can help them make an informed decision.
Titilayo Tatiana Agbadjé, Matthew Menear, Michèle Dugas, Marie-Pierre Gagnon, Samira Abbasgholizadeh Rahimi, Hubert Robitaille, Anik M. C. Giguère, François Rousseau, Brenda J. Wilson, France Légaré   +9 more
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Human 5′ UTR design and variant effect prediction from a massively parallel translation assay

Nature Biotechnology, 2018
The ability to predict the impact of cis-regulatory sequences on gene expression would facilitate discovery in fundamental and applied biology. Here we combine polysome profiling of a library of 280,000 randomized 5′ untranslated regions (UTRs) with deep
Paul J. Sample, Ban Wang, David W. Reid, Vladimir Presnyak, I. McFadyen, D. Morris, Georg Seelig   +6 more
semanticscholar   +1 more source

Investigating the Activities of CAF20 and ECM32 in the Regulation of PGM2 mRNA Translation

Biology
Translation is a fundamental process in biology, and understanding its mechanisms is crucial to comprehending cellular functions and diseases. The regulation of this process is closely linked to the structure of mRNA, as these regions prove vital to ...
Mustafa Al-gafari, Sasi Kumar Jagadeesan, Thomas David Daniel Kazmirchuk, Sarah Takallou, Jiashu Wang, Maryam Hajikarimlou, Nishka Beersing Ramessur, Waleed Darwish, Calvin Bradbury-Jost, Houman Moteshareie, Kamaledin B. Said, Bahram Samanfar, Ashkan Golshani   +12 more
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In Vivo Translatome Profiling in Spinal Muscular Atrophy Reveals a Role for SMN Protein in Ribosome Biology

Cell Reports, 2017
Summary: Genetic alterations impacting ubiquitously expressed proteins involved in RNA metabolism often result in neurodegenerative conditions, with increasing evidence suggesting that translation defects can contribute to disease.
Paola Bernabò, Toma Tebaldi, Ewout J.N. Groen, Fiona M. Lane, Elena Perenthaler, Francesca Mattedi, Helen J. Newbery, Haiyan Zhou, Paola Zuccotti, Valentina Potrich, Hannah K. Shorrock, Francesco Muntoni, Alessandro Quattrone, Thomas H. Gillingwater, Gabriella Viero   +14 more
doaj  

Signaling Pathways Involved in the Regulation of mRNA Translation

Molecular and Cellular Biology, 2018
Translation is a key step in the regulation of gene expression and one of the most energy-consuming processes in the cell. In response to various stimuli, multiple signaling pathways converge on the translational machinery to regulate its function.
Philippe P Roux, I. Topisirovic
semanticscholar   +1 more source