Results 51 to 60 of about 3,070,291 (402)
Proximity-Based Modalities for Biology and Medicine
ACS Central Science, 2023 Molecular proximity orchestrates biological function, and blocking existing proximities is an established therapeutic strategy. By contrast, strengthening or creating neoproximity with chemistry enables modulation of biological processes with high ...
Xingui Liu, A. Ciulli
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Natural variability of Kozak sequences correlates with function in a zebrafish model. [PDF]
PLoS ONE, 2014 In eukaryotes, targeting the small ribosomal subunit to the mRNA transcript requires a Kozak sequence at the translation initiation site. Despite the critical importance of the Kozak sequence to regulation of gene expression, there have been no ...
Steven J Grzegorski +4 more
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TRANSLATING MEDICAL TEXTS FOR LEGAL PURPOSES: A GROWING CHALLENGE FOR COURT TRANSLATORS AND INTERPRETERS [PDF]
, 2012 Przekład tekstów medycznych obejmuje cały szereg różnego typu tekstów, takich jak wypisy szpitalne, epikryzy, artykuły naukowe w czasopismach medycznych, ulotki informacyjne dla pacjenta (PILs) czy też wskazówki dotyczące stosowania leku (IFU).
KOŚCIAŁKOWSKA-OKOŃSKA, Ewa
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The biology of frailty in humans and animals: Understanding frailty and promoting translation
Aging Medicine, 2019 Frailty is a state of high vulnerability to adverse health outcomes. This concept is used to explain the heterogeneity in rates of aging in people of the same age.
E. Bisset, S. Howlett
semanticscholar +1 more source
Predicting translation initiation rates for designing synthetic biology
Frontiers in Bioengineering and Biotechnology, 2014 In synthetic biology, precise control over protein expression is required in order to construct functional biological systems. A core principle of the synthetic biology approach is model-guided design and, based on biological understanding of the process,
Benjamin eReeve +5 more
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Journal of Biomedical Science, 2022 Background With the continuous emergence of new SARS-CoV-2 variants that feature increased transmission and immune escape, there is an urgent demand for a better vaccine design that will provide broader neutralizing efficacy.
I-Jung Lee +40 more
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The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases
Molecular Therapy: Nucleic Acids, 2021 YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms,
Zuyao Chen +3 more
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BrisSynBio:a BBSRC/EPSRC-funded Synthetic Biology Research Centre [PDF]
, 2016 BrisSynBio is the Bristol-based Biotechnology and Biological Sciences Research Council (BBSRC)/Engineering and Physical Sciences Research Council (EPSRC)-funded Synthetic Biology Research Centre. It is one of six such Centres in the U.K.
Race, Paul R +2 more
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Translational systems biology and voice pathophysiology [PDF]
The Laryngoscope, 2009 AbstractObjectives/Hypothesis:Personalized medicine has been called upon to tailor healthcare to an individual's needs. Evidence‐based medicine (EBM) has advocated using randomized clinical trials with large populations to evaluate treatment effects. However, due to large variations across patients, the results are likely not to apply to an individual ...
Nicole Y K, Li +5 more
openaire +2 more sources
Translation of Anticancer Efficacy From Nonclinical Models to the Clinic [PDF]
, 2014 Mouse cancer models have provided critical insights into tumor biology; however, clinical translation of these findings has been challenging. This perspective posits that factors impacting on successful translation start with limitations in capturing ...
Duda, D G +4 more
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