Results 111 to 120 of about 1,485,709 (339)

Disjunctive Logic Programs with Inheritance

open access: yes, 2001
The paper proposes a new knowledge representation language, called ...
Buccafurri, Francesco   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Lost in Translation: Why Organizations Should Facilitate Knowledge Transfer [PDF]

open access: yes
Even if knowledge transfer has been extensively studied both in theory and in practice in the last few years, little analysis has been made regarding rhetoric.
Alexandre Perrin
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Evaluative Grammar and Non-Standard Comparatives: A Cross-Linguistic Analysis of Ukrainian and English

open access: yesLanguages
This study examines non-standard comparative and superlative adjective forms in Ukrainian and English, emphasizing their evaluative meanings and grammatical deviations.
Oksana Kovtun
doaj   +1 more source

Of the use of the “English sector” in trigonometry: what amount of mathematical training was necessary in the 18th century? [PDF]

open access: yes, 2016
In 1723 Edmund Stone published The construction and principal uses of mathematical instruments, which was essentially a translation from the French of Bion’s Traité de la construction et des principaux usages des instrumens de mathématique (1709).
Blanco Abellán, Mónica
core   +2 more sources

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