Results 81 to 90 of about 21,068,915 (362)

Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation

Nature Cell Biology, 2018
N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate.
Huilin Huang, Hengyou Weng, Wen-Ju Sun, Xi Qin, Hailing Shi, Huizhe Wu, B. Zhao, Ana Mesquita, Chang Liu, Celvie L. Yuan, Yueh-Chiang Hu, S. Hüttelmaier, Jennifer Skibbe, R. Su, Xiaolan Deng, Lei Dong, Miao Sun, Chenying Li, S. Nachtergaele, Yungui Wang, Chao Hu, Kyle Ferchen, K. Greis, Xi Jiang, M. Wei, Lianghu Qu, J. Guan, Chuan He, Jianhua Yang, Jianjun Chen   +29 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Modeling the Linguistic Topology of Translation Process: General Principles

Виртуальная коммуникация и социальные сети
Cognitive research in translation is currently at its peak. The authors studied L. V. Kushnina’s synergetic concept of translation space in an interaction with the topological fields of translation to develop a linguistic topological model of translation
Anna I. Krivoruchko, Sinxiun Kan
doaj   +1 more source

International Public Health Research Involving Interpreters: a Case Study from Bangladesh [PDF]

, 2005
Background: Cross-cultural and international research are important components of public health research, but the challenges of language barriers and working with interpreters are often overlooked, particularly in the case of qualitative research ...
A Bowden, A Bowling, A Fontana, A Herod, A Holliday, A Oakley, B Flyvbjerg, B Jentsch, B Temple, B Temple, B Temple, BS Turner, D Armstrong, D Lupton, E Teijlingen van, Edwin van Teijlingen, EL Jones, Emma Pitchforth, H Bradby, H Richards, HJ Rubin, I Dyck, J Mason, J Miller, J Platt, JC Mitchell, JR Cutcliffe, K Bhopal, K Nunkoosing, KM Eisenhardt, M Birbili, S Bassnett, S Fukuhara, S Hunt, S Twinn, T Blanchet   +35 more
core   +4 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

NATURALNESS IN TRANSLATION OF ENGLISH NOVEL INTO INDONESIAN [PDF]

, 2015
Naturalness in translation is a very important point in relation to translation product quality. This paper is a research-based article on the translation of English-novel into Indonesian.
Baharuddin, Baharuddin
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Translations| “The Task of the Translator”: Comparing the Views of the Client and the Translator

International Journal of Communication, 2016
As a consequence of globalization and corporate restructuring processes, most translators are now freelance and generally work for multiple clients on a project basis.
Hanna Risku, Christina Pein-Weber, Jelena Milosevic   +2 more
doaj   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source