Results 91 to 100 of about 459,862 (260)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

THE TRANSLATION OF METAPHORS IN HARRY POTTER AND THE CHAMBER OF SECRETS FROM ENGLISH TO INDONESIAN

open access: yesEnglish Review: Journal of English Education, 2015
Translation is undoubtedly an important but at the same time difficult work. Metaphors are among the potential areas of translation problem. This study aimed at describing how metaphors in the novel Harry Potter and the Chamber of Secrets are translated ...
Khairuddin
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Übersetzungsproblematik in der schriftlichen Kommunikation: Eine Fallstudie zum Brief [PDF]

open access: yesLinguistische Treffen in Wrocław
This study examines the challenges of translating written communication, historical letters, especially the correspondence between Professor Çabej and the researcher Babinger from 1963.
Vezire Krasniqi   +2 more
doaj   +1 more source

Knowledge translation strategies to support the sustainability of evidence-based interventions in healthcare: a scoping review. [PDF]

open access: yesImplement Sci, 2023
Flynn R   +7 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Strategies of Translating Lexical Collocations in Literary Texts from English into Arabic

open access: yesالآداب للدراسات اللغوية والأدبية, 2021
The present study investigates the translation of lexical collocations in literary texts from English into Arabic in light of the translation strategies used by some translators. Two English literary works have been translated into Arabic are used. (151)
عبده أحمد علي منصر
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy