Results 81 to 90 of about 459,862 (260)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Subtitle Translation: Cultural Components in the Translation of the Film Qu'est-ce qu'on a fait au bon Dieu?

open access: yesSelçuk Üniversitesi Edebiyat Fakültesi Dergisi, 2018
Subtitle translation which is one of the oldest types of translation, can be defined as translation of audio-visual constituents in the source language simultaneously into the target language in a limited duration.
Gülhanım Ünsal
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Penerjemahan Kata Budaya dalam Laskar Pelangi ke Dalam Novel Bahasa Jepang Niji No Shoonentachi

open access: yesParadigma: Jurnal Kajian Budaya, 2017
This research aims to describe the method and technique of the translation of cultural words in “Laskar Pelangi” into a Japanese novel, “Niji no Shoonentachi.” This research uses a descriptive approach with comparative models.
Mike Nurjana
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Literature and translation in Burkina Faso: the case of Fidèle P. Rouamba’s novel Le Carnaval de la mort

open access: yesTydskrif vir Letterkunde, 2019
Translation, considered as a product of linguistic diversity or the confusion following the fall of the Tower of Babel, represents an act of communication.
Lalbila Yoda
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Translating Korean Nature. Translation Strategies in Lithuanian and English Literary Translation

open access: yesResearch in Language, 2020
World literatures today often impose a separation of narratives from their geographic and linguistic origins. Translated versions of literary texts that were created and received within local cultural contexts, when translated, enter new, foreign contexts.
openaire   +5 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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