Results 111 to 120 of about 1,311,801 (275)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

La función de la teoría de la traducción en el desarrollo de las prácticas traductivas

open access: yesPhilologia Romanistica Cultura
The aim of the article is to specify the role of translation theory in the field of the translation process. Within the principles of translation, all phases of translation are analysed, as well as the need to understand the source text from a ...
Sofia Tileschová
doaj   +1 more source

Penerjemahan Kata Budaya dalam Laskar Pelangi ke Dalam Novel Bahasa Jepang Niji No Shoonentachi

open access: yesParadigma: Jurnal Kajian Budaya, 2017
This research aims to describe the method and technique of the translation of cultural words in “Laskar Pelangi” into a Japanese novel, “Niji no Shoonentachi.” This research uses a descriptive approach with comparative models.
Mike Nurjana
doaj   +1 more source

Micro-strategies of Contextualization Cross-national Transfer of Socially Responsible Investment [PDF]

open access: yes
This paper examines how individuals select and mobilize local institutions when they transfer business practices across societies that are construed as dissimilar to one another.
Eva Boxenbaum, Jean-Pascal Gond
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Resolving the Quantitative-Qualitative Dilemma: A Critical Realist Approach [PDF]

open access: yes, 2007
The philosophical issues underpinning the quantitative–qualitative divide in educational research are examined. Three types of argument which support a resolution are considered: pragmatism, false duality and warranty through triangulation. In addition a
Scott, David
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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