Results 91 to 100 of about 419,375 (265)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Translation Strategies of Javanese Addresses Terms into Arabic in Gadis Kretek Novel

open access: yesSuar Betang
The differences in address systems between Javanese and Arabic cultures require translation strategies to achieve equivalence. The address systems in these two cultures not only reflect personal relationships, but also distinct social structures and ...
Muhamad Saiful Mukminin, Sajarwa
doaj   +1 more source

Crohn's and Colitis Canada's 2021 Impact of COVID-19 & Inflammatory Bowel Disease in Canada: A Knowledge Translation Strategy. [PDF]

open access: yesJ Can Assoc Gastroenterol, 2021
Kaplan GG   +25 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Idioms in Translation: A Comparative Analysis of Three Persian Translations of The Yard and the Dogs of My Father

open access: yesپژوهشنامه ادبیات کردی, 2019
Idioms form a significant part of a language. Using idioms in their works, literary writers try to avoid the direct style of writing, increase the influence of their texts and manifest their writing abilities and skills; Doing this, they create a ...
Serveh Menbari, Shahin Heidari
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Stumbling Blocks in the Translation of English Road Traffic Terminology

open access: yesACROSS
Under the conditions of a rapid increase in the number of vehicles and the extension of the European Union borders, the investigation of road traffic terminology acquires vital importance, as language has always been a means of reflecting non ...
Inga STOIANOVA
doaj   +1 more source

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