Results 131 to 140 of about 9,270 (176)

3S-DB identifies an RNA repository facilitating stop codon readthrough for selenocysteine insertion and selenoproteome expansion

Redox Biology
Selenoproteins contain the selenocysteine (Sec, U), which is essential for redox regulation due to its reactive selenol group. The current set of 25 human selenoproteins was defined by the presence of SECIS elements in the 3’ UTR coupled with in-frame ...
Chenfang Si, Lu Zhang, Jing Gao, Kongyan Niu, Yunxia Li, Nan Liu, Bing Shan, Yaoyang Zhang   +7 more
doaj   +1 more source

Transcript-specific induction of stop codon readthrough using a CRISPR-dCas13 system

EMBO Reports
Stop codon readthrough (SCR) is the process where translation continues beyond a stop codon on an mRNA. Here, we describe a strategy to enhance or induce SCR in a transcript-selective manner using a CRISPR-dCas13 system.
Lekha E Manjunath, Anumeha Singh, Sangeetha Devi Kumar, Kirtana Vasu, Debaleena Kar, Karthi Sellamuthu, Sandeep M Eswarappa   +6 more
doaj   +1 more source

Tissue-specific regulation of translational readthrough tunes functions of the traffic jam transcription factor. [PDF]

Nucleic Acids Res, 2022
Karki P, Carney TD, Maracci C, Yatsenko AS, Shcherbata HR, Rodnina MV.   +5 more
europepmc   +1 more source

Therapeutic Nonsense Suppression Modalities: From Small Molecules to Nucleic Acid-Based Approaches

Biomedicines
Nonsense mutations are genetic mutations that create premature termination codons (PTCs), leading to truncated, defective proteins in diseases such as cystic fibrosis, neurofibromatosis type 1, Dravet syndrome, Hurler syndrome, Beta thalassemia ...
Pedro Morais, Rui Zhang, Yi-Tao Yu
doaj   +1 more source

Alteration of the translational readthrough isoform AQP4ex induces redistribution and downregulation of AQP4 in human glioblastoma. [PDF]

Cell Mol Life Sci, 2022
Valente O, Messina R, Ingravallo G, Bellitti E, Zimatore DS, de Gennaro L, Abbrescia P, Pati R, Palazzo C, Nicchia GP, Trojano M, Signorelli F, Frigeri A.   +12 more
europepmc   +1 more source

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. [PDF]

Nat Commun, 2021
Sharma J, Du M, Wong E, Mutyam V, Li Y, Chen J, Wangen J, Thrasher K, Fu L, Peng N, Tang L, Liu K, Mathew B, Bostwick RJ, Augelli-Szafran CE, Bihler H, Liang F, Mahiou J, Saltz J, Rab A, Hong J, Sorscher EJ, Mendenhall EM, Coppola CJ, Keeling KM, Green R, Mense M, Suto MJ, Rowe SM, Bedwell DM.   +29 more
europepmc   +1 more source

Translational readthrough of ciliopathy genes BBS2 and ALMS1 restores protein, ciliogenesis and function in patient fibroblasts. [PDF]

EBioMedicine, 2021
Eintracht J, Forsythe E, May-Simera H, Moosajee M.   +3 more
europepmc   +1 more source

Properties of Non-Aminoglycoside Compounds Used to Stimulate Translational Readthrough of PTC Mutations in Primary Ciliary Dyskinesia. [PDF]

Int J Mol Sci, 2021
Dabrowski M, Bukowy-Bieryllo Z, Jackson CL, Zietkiewicz E.   +3 more
europepmc   +1 more source

Faculty Opinions recommendation of Translation readthrough mitigation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2018
Siegfried Hekimi, Alycia Noë
openaire   +2 more sources

RESCUING P53 BY NEW TRANSLATIONAL READTHROUGH INDUCING DRUGS

Nonsense mutations represent a distinct category of mutations, characterized by converting an amino acid coding triplet into a premature termination codon (PTC). This results in a notable reduction in cytosolic mRNA levels, ultimately leading to the premature halting of translation and the production of truncated and non-functional proteins.
Giulia culletta, davide ricci, marco tutone, anna maria almerico, m. menditto, laura lentini, raffaella melfi, andrea pace, p. s. carollo, ivana pibiri   +9 more
openaire   +1 more source