Results 121 to 130 of about 9,270 (176)

Fluorescent reporters give new insights into antibiotics-induced nonsense and frameshift mistranslation

Scientific Reports
We developed a reporter system based on simultaneous expression of two fluorescent proteins: GFP as a reporter of the capacity of protein synthesis and mutated mScarlet-I as a reporter of translational errors.
Mariliis Hinnu, Marta Putrinš, Karin Kogermann, Niilo Kaldalu, Tanel Tenson   +4 more
doaj   +1 more source

Fidelity of protein synthesis affects the readthrough translation of tobacco mosaic virus RNA [PDF]

FEBS Letters, 1981
1. Introduction In many viral systems [l-5] and in the case of P-globin [6], translation of mRNA can continue past the termination codon by a process known as read- through. In the abscence of suppressor tRNAs, such natural termination suppression is likely to involve misreading of the termination codon.
openaire   +2 more sources

Beyond the stop: Oxadiazole TRIDs restore LRBA protein expression in nonsense-driven primary immunodeficiency

Molecular Therapy: Nucleic Acids
Nonsense mutations are among the genetic causes of LRBA (lipopolysaccharide-responsive beige-like anchor) deficiency, a rare autosomal-recessive immunodeficiency disorder.
Ignazio Fiduccia, Emanuele Vitale, Riccardo Varrica, Davide Ricci, Sefora Marino, Antonino Zito, Andrea Pace, Alain Colige, Michel Moutschen, Yasmin Borutzki, Andrea Bileck, Samuel M. Meier-Menches, Laura Lentini, Ivana Pibiri   +13 more
doaj   +1 more source

The Inhibition of Gag-Pol Expression by the Restriction Factor Shiftless Is Dispensable for the Restriction of HIV-1 Infection

Viruses
The interferon-induced host cell protein Shiftless (SFL) inhibits −1 programmed ribosomal frameshifting (−1PRF) required for the expression of HIV-1 Gal-Pol and the formation of infectious HIV-1 particles.
Niklas Jäger, Shreya Ahana Ayyub, Frank Peske, David Liedtke, Jens Bohne, Markus Hoffmann, Marina V. Rodnina, Stefan Pöhlmann   +7 more
doaj   +1 more source

The alphaviruses: gene expression, replication, and evolution [PDF]

, 1994
The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for these viruses.
Strauss, Ellen G., Strauss, James H.
core   +1 more source

Emerging Personalized Opportunities for Enhancing Translational Readthrough in Rare Genetic Diseases and Beyond. [PDF]

Int J Mol Sci, 2023
Wagner RN, Wießner M, Friedrich A, Zandanell J, Breitenbach-Koller H, Bauer JW.   +5 more
europepmc   +1 more source

Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures [PDF]

, 2007
Sequencing of multiple related species followed by comparative genomics analysis constitutes a powerful approach for the systematic understanding of any genome.
Pachter, Lior, Stark, Alexander
core   +1 more source

Engineered tRNAs efficiently suppress CDKL5 premature termination codons

Scientific Reports
The CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental disorder characterized by early-onset epilepsy, intellectual disability, motor and visual dysfunctions.
Stefano Pezzini, Aurora Mustaccia, Pierre Aboa, Giorgia Faustini, Alessio Branchini, Mirko Pinotti, Angelisa Frasca, Joseph J. Porter, John D. Lueck, Nicoletta Landsberger   +9 more
doaj   +1 more source

Sequence elements controlling expression of Barley stripe mosaic virus subgenomic RNAs in vivo. [PDF]

, 2003
Barley stripe mosaic virus (BSMV) contains three positive-sense, single-stranded genomic RNAs, designated alpha, beta, and gamma, that encode seven major proteins and one minor translational readthrough protein. Three proteins (alphaa, betaa, and gammaa)
Bragg, Jennifer N, Jackson, Andrew O, Johnson, Jennifer A, Lawrence, Diane M   +3 more
core  

Programmed Translational Readthrough in Drosophila melanogaster [PDF]

, 2022
openaire   +2 more sources