Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains [PDF]
, 2014 The Type VII protein secretion system, found in Gram-positive bacteria, secretes small proteins, containing a conserved W-x-G amino acid sequence motif, to the growth medium.
Cao, Zhen Ping +11 more
core +5 more sources
Journal of Neurochemistry, Volume 170, Issue 3, March 2026.The study investigates the functional consequences of INTS11 loss‐of‐function (LoF), a genetic alteration linked to neurodevelopmental disorder (NDD), using zebrafish as an in vivo model. To model ints11 deficiency, two complementary approaches are applied: morpholino‐mediated knock‐down and CRISPR–Cas9 transient knock‐out, establishing ints11‐LoF ...
Anna Pistocchi +9 more
wiley +1 more source
Bloom syndrome: research and data priorities for the development of precision medicine as identified by some affected families [PDF]
, 2018 Bloom syndrome (BS) is a rare, autosomal recessive genetic disorder characterized by short stature, a skin rash associated with sun exposure, and an elevated likelihood of developing cancers of essentially all types, beginning at an early age.
Campbell, Mary Beth +8 more
core +1 more source
Differential regulation of translational stress responses by herpesvirus ubiquitin deconjugases
The FEBS Journal, Volume 293, Issue 4, Page 1024-1044, February 2026.Translating viral mRNAs is challenging due to structural features that may slow translation or induce ribosome stalling. The viral ubiquitin deconjugases encoded by human pathogenic herpesviruses regulate the cellular response to ribosomal stress by inhibiting various branches of the Ribosomal Quality Control (RQC) and activating Ribosomal Stress ...
Jiangnan Liu +3 more
wiley +1 more source
Non-canonical Translation in Plant RNA Viruses [PDF]
, 2017 Viral protein synthesis is completely dependent upon the host cell's translational machinery. Canonical translation of host mRNAs depends on structural elements such as the 5′ cap structure and/or the 3′ poly(A) tail of the mRNAs.
Manuel Miras +3 more
core +1 more source
Angewandte Chemie International Edition, Volume 65, Issue 1, 2 January 2026.Genetic code expansion with a unique hyper‐fluorinated phosphotyrosine analog. In this work, we successfully incorporated the unnatural amino acid pentafluorophosphato‐difluoromethyl‐phenylalanine, carrying seven fluorine atoms and a permanent negative charge into three different proteins via the use of mutated orthogonal aminoacyl‐tRNA synthetases ...
Anna Magdalena Ambros +10 more
wiley +1 more source
Quantitative nucleotide level analysis of regulation of translation in response to depolarization of cultured neural cells [PDF]
, 2017 Studies on regulation of gene expression have contributed substantially to understanding mechanisms for the long-term activity-dependent alterations in neural connectivity that are thought to mediate learning and memory.
Dalal, Jasbir S +5 more
core +2 more sources
Cross‐Species Insights Into Gamma Herpesvirus Transcriptomes: Long‐Read and Multi‐Omics Perspectives
Journal of Medical Virology, Volume 98, Issue 1, January 2026.ABSTRACT Comparative transcriptome analyses of gamma herpesviruses have been revolutionized by long‐read sequencing and integrative multi‐omics approaches, enabling unprecedented resolution of viral gene expression. Cross‐species studies of Kaposi's sarcoma‐associated herpesvirus (KSHV), Epstein–Barr virus (EBV), and murine gamma herpesvirus 68 (MHV68)
Ritu Shekhar +4 more
wiley +1 more source
A structural and functional analysis of opal stop codon translational readthrough during Chikungunya Virus replication [PDF]
J Gen Virol, 2023 Li R, Sun K, Tuplin A, Harris M.
europepmc +2 more sources
Maize chlorotic mottle virus exhibits low divergence between differentiated regional sub-populations. [PDF]
, 2018 Maize chlorotic mottle virus has been rapidly spreading around the globe over the past decade. The interactions of maize chlorotic mottle virus with Potyviridae viruses causes an aggressive synergistic viral condition - maize lethal necrosis, which can ...
Baulcombe, David C +5 more
core +2 more sources