Strategies against Nonsense: Oxadiazoles as Translational Readthrough-Inducing Drugs (TRIDs). [PDF]
Int J Mol Sci, 2019 This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations.
Campofelice A +6 more
europepmc +9 more sources
Functional Translational Readthrough: A Systems Biology Perspective. [PDF]
PLoS Genetics, 2016 Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR).
Fabian Schueren, Sven Thoms
doaj +5 more sources
Defining the high-translational readthrough stop codon context. [PDF]
PLoS GeneticsTranslational termination is not entirely efficient and competes with elongation, which might result in translational readthrough (TR). TR occurs when a near-cognate tRNA binds to a stop codon, (mis)interpreting it as a sense codon and producing a C ...
Daniela Smoljanow +3 more
doaj +3 more sources
Correction: Functional Translational Readthrough: A Systems Biology Perspective. [PDF]
PLoS Genetics, 2016 [This corrects the article DOI: 10.1371/journal.pgen.1006196.].
PLOS Genetics Staff
doaj +4 more sources
A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay. [PDF]
PLoS ONE, 2017 The nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs containing premature termination codons, limiting the expression of potentially deleterious truncated proteins.
Stacey L Baker, J Robert Hogg
doaj +4 more sources
Programmed translational readthrough generates antiangiogenic VEGF-Ax. [PDF]
Cell, 2014 Translational readthrough, observed primarily in less complex organisms from viruses to Drosophila, expands the proteome by translating select transcripts beyond the canonical stop codon. Here, we show that vascular endothelial growth factor A (VEGFA) mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating ...
Eswarappa SM +9 more
europepmc +6 more sources
Translation initiation factor eIF3 promotes programmed stop codon readthrough. [PDF]
Nucleic Acids Research, 2015 Programmed stop codon readthrough is a post-transcription regulatory mechanism specifically increasing proteome diversity by creating a pool of C-terminally extended proteins.
Beznoskova, Petra +4 more
core +5 more sources
Readthrough compounds for nonsense mutations: bridging the translational gap
Trends in Molecular Medicine, 2023 Approximately 10% of all pathological mutations are nonsense mutations that are responsible for several severe genetic diseases for which no treatment regimens are currently available. The most widespread strategy for treating nonsense mutations is by enhancing ribosomal readthrough of premature termination codons (PTCs) to restore the production of ...
Spelier, Sacha +4 more
openaire +5 more sources
Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals
eLife, 2014 Translational readthrough gives rise to low abundance proteins with C-terminal extensions beyond the stop codon. To identify functional translational readthrough, we estimated the readthrough propensity (RTP) of all stop codon contexts of the human ...
Fabian Schueren +6 more
doaj +4 more sources
Multifaceted regulation of translational readthrough by RNA replication elements in a tombusvirus. [PDF]
PLoS Pathogens, 2011 Translational readthrough of stop codons by ribosomes is a recoding event used by a variety of viruses, including plus-strand RNA tombusviruses. Translation of the viral RNA-dependent RNA polymerase (RdRp) in tombusviruses is mediated using this strategy
Peter A Cimino +4 more
doaj +4 more sources