Results 11 to 20 of about 5,883 (112)

Defining the high-translational readthrough stop codon context. [PDF]

PLoS Genetics
Translational termination is not entirely efficient and competes with elongation, which might result in translational readthrough (TR). TR occurs when a near-cognate tRNA binds to a stop codon, (mis)interpreting it as a sense codon and producing a C ...
Daniela Smoljanow, Dennis Lebeda, Julia Hofhuis, Sven Thoms   +3 more
doaj   +2 more sources

Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codons [PDF]

Molecular Medicine, 2018
Premature termination codons (PTCs) in the coding regions of mRNA lead to the incorrect termination of translation and generation of non-functional, truncated proteins.
Maciej Dabrowski, Zuzanna Bukowy-Bieryllo, Ewa Zietkiewicz   +2 more
doaj   +2 more sources

Anticodon-edited tRNA enables translational readthrough of COL4A5 premature termination codons. [PDF]

PLoS ONE
Alport syndrome is caused by variants in COL4A3, COL4A4, or COL4A5, which encode the α3α4α5 chains of type IV collagen. These variants result in defects in the glomerular basement membrane (GBM) and impaired kidney function.
Kohei Omachi, Joseph J Porter, John D Lueck, Jeffrey H Miner   +3 more
doaj   +2 more sources

Translational readthrough therapy for ADPKD induces polycystin1 expression and partially rescues functional deficits in PKD1 mutant cells [PDF]

Scientific Reports
Autosomal-Dominant Polycystic Kidney Disease, ADPKD, is the most common genetic kidney disease affecting 1:1000 people worldwide. It is caused by mutations in the PKD1 (~ 80%) or PKD2 gene (~ 15%).
Elena Torban, Lucie Canaff, Sima Babayeva, Nadezda Kachurina, Chen-Fang Chung, Albert C. M. Ong, Ahsan Alam, Paul R. Goodyer   +7 more
doaj   +2 more sources

Correction: Functional Translational Readthrough: A Systems Biology Perspective. [PDF]

PLoS Genetics, 2016
[This corrects the article DOI: 10.1371/journal.pgen.1006196.].
PLOS Genetics Staff
doaj   +2 more sources

Readthrough Approach Using NV Translational Readthrough-Inducing Drugs (TRIDs): A Study of the Possible Off-Target Effects on Natural Termination Codons (NTCs) on TP53 and Housekeeping Gene Expression [PDF]

International Journal of Molecular Sciences, 2023
Marco Tutone, Ivana Pibiri, Laura Lentini   +2 more
exaly   +2 more sources

RNA Cis-Elements Involved in Animal Virus Stop Codon Readthrough: Stop Codon Context and Downstream RNA Structures [PDF]

Viruses
Stop codon readthrough is a noncanonical translation strategy employed by certain RNA viruses, in which a viral termination codon is either decoded by host near-cognate tRNAs or canonically recognized by the class I release factor (RF, eRF1 in eukaryotes)
Nobuhiko Kamoshita
doaj   +2 more sources

Emerging Personalized Opportunities for Enhancing Translational Readthrough in Rare Genetic Diseases and Beyond [PDF]

International Journal of Molecular Sciences, 2023
Roland Wagner, Johann W Bauer, Johanna Zandanell   +2 more
exaly   +2 more sources

Molecular Insights into Determinants of Translational Readthrough and Implications for Nonsense Suppression Approaches [PDF]

International Journal of Molecular Sciences, 2020
Mirko Pinotti, Alessio Branchini, Silvia Lombardi   +2 more
exaly   +2 more sources

Potentiation by Protein Synthesis Inducers of Translational Readthrough of Pathogenic Premature Termination Codons in PTEN Isoforms [PDF]

Cancers
Rafael Pulido, Caroline E Nunes-Xavier, Leire Torices   +2 more
exaly   +2 more sources