Let‐7a‐regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor [PDF]
EMBO Journal, 2019 Paul L Fox +2 more
exaly +2 more sources
Strategies against Nonsense: Oxadiazoles as Translational Readthrough-Inducing Drugs (TRIDs) [PDF]
International Journal of Molecular Sciences, 2019 Marco Tutone +2 more
exaly +2 more sources
Heterologous stop codon readthrough of metazoan readthrough candidates in yeast. [PDF]
PLoS ONE, 2013 Recent analysis of genomic signatures in mammals, flies, and worms indicates that functional translational stop codon readthrough is considerably more abundant in metazoa than previously recognized, but this analysis provides only limited clues about the
Clara S Chan +2 more
doaj +1 more source
Cell Reports, 2023 Summary: Suppression of premature termination codons (PTCs) by translational readthrough is a promising strategy to treat a wide variety of severe genetic diseases caused by nonsense mutations. Here, we present two potent readthrough promoters—NVS1.1 and
Lukas-Adrian Gurzeler +18 more
doaj +1 more source
The functional readthrough extension of malate dehydrogenase reveals a modification of the genetic code [PDF]
Open Biology, 2016 Translational readthrough gives rise to C-terminally extended proteins, thereby providing the cell with new protein isoforms. These may have different properties from the parental proteins if the extensions contain functional domains.
Julia Hofhuis +6 more
doaj +1 more source
Recoding of Nonsense Mutation as a Pharmacological Strategy
Biomedicines, 2023 Approximately 11% of genetic human diseases are caused by nonsense mutations that introduce a premature termination codon (PTC) into the coding sequence. The PTC results in the production of a potentially harmful shortened polypeptide and activation of a
Gazmend Temaj +5 more
doaj +1 more source
Ribosomal readthrough at a short UGA stop codon context triggers dual localization of metabolic enzymes in Fungi and animals. [PDF]
PLoS Genetics, 2014 Translation of mRNA into a polypeptide chain is a highly accurate process. Many prokaryotic and eukaryotic viruses, however, use leaky termination of translation to optimize their coding capacity.
Alina C Stiebler +6 more
doaj +1 more source
Multifaceted regulation of translational readthrough by RNA replication elements in a tombusvirus. [PDF]
PLoS Pathogens, 2011 Translational readthrough of stop codons by ribosomes is a recoding event used by a variety of viruses, including plus-strand RNA tombusviruses. Translation of the viral RNA-dependent RNA polymerase (RdRp) in tombusviruses is mediated using this strategy
Peter A Cimino +4 more
doaj +1 more source
Pharmaceuticals Promoting Premature Termination Codon Readthrough: Progress in Development
Biomolecules, 2023 Around 11% of all known gene lesions causing human genetic diseases are nonsense mutations that introduce a premature stop codon (PTC) into the protein-coding gene sequence.
Shan Li +9 more
doaj +1 more source
Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals
eLife, 2014 Translational readthrough gives rise to low abundance proteins with C-terminal extensions beyond the stop codon. To identify functional translational readthrough, we estimated the readthrough propensity (RTP) of all stop codon contexts of the human ...
Fabian Schueren +6 more
doaj +1 more source