RNA Biology, 2022 Delicate variances in the translational machinery affect how efficiently different organisms approach protein synthesis. Determining the scale of this effect, however, requires knowledge on the differences of mistranslation levels.
Karl Jürgenstein +5 more
doaj +1 more source
Atypical RNA Elements Modulate Translational Readthrough in Tobacco Necrosis Virus D. [PDF]
J Virol, 2017 ABSTRACT Tobacco necrosis virus, strain D (TNV-D), is a positive-strand RNA virus in the genus Betanecrovirus and family Tombusviridae . The production of its RNA-dependent RNA polymerase, p82, is achieved by translational readthrough.
Newburn LR, White KA.
europepmc +4 more sources
An Equilibrium-Dependent Retroviral mRNA Switch Regulates Translational Recoding [PDF]
, 2011 Most retroviruses require translational recoding of a viral messenger RNA stop codon to maintain a precise ratio of structural (Gag) and enzymatic (Pol) proteins during virus assembly.
D'Souza, Victoria M +6 more
core +1 more source
Control of gene expression in the retrotransposon Tca2 [PDF]
, 2007 BACKGROUND:In the C. albicans retrotransposon Tca2, the gag and pol ORFs are separated by a UGA stop codon, 3' of which is a potential RNA pseudoknot. It is unclear how the Tca2 gag UGA codon is bypassed to allow pol expression.
Brunton, Fiona +5 more
core +3 more sources
Evaluation of Pharmacological Rescue of Melanocortin-4 Receptor Nonsense Mutations by Aminoglycoside
Life, 2022 The melanocortin-4 receptor (MC4R) is critical for central satiety regulation, therefore presenting a potent target for pharmacological obesity treatment. Melanocortin-4 receptor mutations prevalently cause monogenetic obesity.
Friederike Höpfner +7 more
doaj +1 more source
AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation. [PDF]
, 2018 In addition to acting as template for protein synthesis, messenger RNA (mRNA) often contains sensory sequence elements that regulate this process1,2.
Andreev, Dmitry E. +13 more
core +1 more source
Functional rescue of REP1 following treatment with PTC124 and novel derivative PTC-414 in human choroideremia fibroblasts and the nonsense-mediated zebrafish model [PDF]
, 2016 Choroideremia (CHM) is an X-linked chorioretinal dystrophy that is caused by mutations within a single gene, CHM Currently no effective treatment exists for these patients.
Coffey, P +9 more
core +1 more source
Regulated expression by readthrough translation from a plasmid-encoded beta-galactosidase [PDF]
Journal of Bacteriology, 1978 We have characterized expression of beta-galactosidase from a plasmid cloning vehicle, pBGP120, which carries most of the lacZ gene and contains a single EcoRI site near the end of lacZ. In addition, we have examined expression of heterologous DNA inserted at the position of the EcoRI site.
P, O'Farrell, B, Polisky, D H, Gelfand
openaire +2 more sources
Translation termination depends on the sequential ribosomal entry of eRF1 and eRF3.
, 2019 Translation termination requires eRF1 and eRF3 for polypeptide-and tRNA-release on stop codons. Additionally, Dbp5/DDX19 and Rli1/ABCE1 are required; however, their function in this process is currently unknown.
Beissel , C. +5 more
core +1 more source
The expanding toolkit of translating ribosome affinity purification [PDF]
, 2017 Translating ribosome affinity purification is a method initially developed for profiling mRNA from genetically defined cell types in complex tissues. It has been applied both to identify target molecules in cell types that are important for controlling a
Dougherty, Joseph D
core +2 more sources