Results 71 to 80 of about 5,883 (112)

Reading through the stop codon: Programmed translational readthrough as a regulatory strategy in bacteria

Asian Journal of Medical Sciences
In the received wisdom of molecular biology, stop codons, UAA, UAG, and UGA, are inviolable signals: The full stops at which the ribosome releases its nascent polypeptide and dissociates from the messenger RNA (mRNA).
Ruby Dhar , Arun Kumar, Subhradip Karmakar   +2 more
doaj   +1 more source

The Inhibition of Gag-Pol Expression by the Restriction Factor Shiftless Is Dispensable for the Restriction of HIV-1 Infection

Viruses
The interferon-induced host cell protein Shiftless (SFL) inhibits −1 programmed ribosomal frameshifting (−1PRF) required for the expression of HIV-1 Gal-Pol and the formation of infectious HIV-1 particles.
Niklas Jäger, Shreya Ahana Ayyub, Frank Peske, David Liedtke, Jens Bohne, Markus Hoffmann, Marina V. Rodnina, Stefan Pöhlmann   +7 more
doaj   +1 more source

Engineered tRNAs efficiently suppress CDKL5 premature termination codons

Scientific Reports
The CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental disorder characterized by early-onset epilepsy, intellectual disability, motor and visual dysfunctions.
Stefano Pezzini, Aurora Mustaccia, Pierre Aboa, Giorgia Faustini, Alessio Branchini, Mirko Pinotti, Angelisa Frasca, Joseph J. Porter, John D. Lueck, Nicoletta Landsberger   +9 more
doaj   +1 more source

Investigation of PTC124-mediated translational readthrough in a retinal organoid model of AIPL1-associated Leber congenital amaurosis. [PDF]

Stem Cell Reports, 2022
Leung A, Sacristan-Reviriego A, Perdigão PRL, Sai H, Georgiou M, Kalitzeos A, Carr AF, Coffey PJ, Michaelides M, Bainbridge J, Cheetham ME, van der Spuy J.   +11 more
europepmc   +1 more source

Environment modulates protein heterogeneity through transcriptional and translational stop codon readthrough

Nature Communications
Stop codon readthrough events give rise to longer proteins, which may alter the protein’s function, thereby generating short-lasting phenotypic variability from a single gene.
Maria Luisa Romero Romero, Jonas Poehls, Anastasiia Kirilenko, Doris Richter, Tobias Jumel, Anna Shevchenko, Agnes Toth-Petroczy   +6 more
doaj   +1 more source

3S-DB identifies an RNA repository facilitating stop codon readthrough for selenocysteine insertion and selenoproteome expansion

Redox Biology
Selenoproteins contain the selenocysteine (Sec, U), which is essential for redox regulation due to its reactive selenol group. The current set of 25 human selenoproteins was defined by the presence of SECIS elements in the 3’ UTR coupled with in-frame ...
Chenfang Si, Lu Zhang, Jing Gao, Kongyan Niu, Yunxia Li, Nan Liu, Bing Shan, Yaoyang Zhang   +7 more
doaj   +1 more source

Tissue-specific regulation of translational readthrough tunes functions of the traffic jam transcription factor. [PDF]

Nucleic Acids Res, 2022
Karki P, Carney TD, Maracci C, Yatsenko AS, Shcherbata HR, Rodnina MV.   +5 more
europepmc   +1 more source

Transcript-specific induction of stop codon readthrough using a CRISPR-dCas13 system

EMBO Reports
Stop codon readthrough (SCR) is the process where translation continues beyond a stop codon on an mRNA. Here, we describe a strategy to enhance or induce SCR in a transcript-selective manner using a CRISPR-dCas13 system.
Lekha E Manjunath, Anumeha Singh, Sangeetha Devi Kumar, Kirtana Vasu, Debaleena Kar, Karthi Sellamuthu, Sandeep M Eswarappa   +6 more
doaj   +1 more source

Alteration of the translational readthrough isoform AQP4ex induces redistribution and downregulation of AQP4 in human glioblastoma. [PDF]

Cell Mol Life Sci, 2022
Valente O, Messina R, Ingravallo G, Bellitti E, Zimatore DS, de Gennaro L, Abbrescia P, Pati R, Palazzo C, Nicchia GP, Trojano M, Signorelli F, Frigeri A.   +12 more
europepmc   +1 more source

Novel Correctors and Potentiators Enhance Translational Readthrough in CFTR Nonsense Mutations. [PDF]

Am J Respir Cell Mol Biol, 2021
Mutyam V, Sharma J, Li Y, Peng N, Chen J, Tang LP, Falk Libby E, Singh AK, Conrath K, Rowe SM.   +9 more
europepmc   +1 more source