Results 171 to 180 of about 617,976 (302)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

BOLL-Containing Aggregates Mediate the Translational Regulation During Human Oogenesis. [PDF]

Cell Prolif
Li Y, Mao L, Liang B, Xie L, Xiang W, Kee K.   +5 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Internal ribosomal entry site lacks secondary structure

, 2007
The search for mechanisms of translational regulation has yielded many experimentally identified internal ribosome entry sites (IRES). Because of the lack of sequence similarity among the experimentally IRESs, it is widely assumed that IRESs posses ...
Xuhua Xia
core   +1 more source

Corrigendum: Receptor of advanced glycation end products deficiency attenuates cisplatin-induced acute nephrotoxicity by inhibiting apoptosis, inflammation and restoring fatty acid oxidation

Frontiers in Pharmacology, 2022
Qiang Wang, Qiang Wang, Yuemei Xi, Yuemei Xi, Binyang Chen, Binyang Chen, Hairong Zhao, Hairong Zhao, Wei Yu, Wei Yu, De Xie, De Xie, Weidong Liu, Weidong Liu, Furong He, Furong He, Chenxi Xu, Chenxi Xu, Jidong Cheng, Jidong Cheng   +19 more
doaj   +1 more source

Post-translational regulation of human D-3-phosphoglycerate dehydrogenase in Alzheimer's disease. [PDF]

Protein Sci
Zerbini E, Riva D, Maffioli E, Tedeschi G, Sacchi S, Pollegioni L.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Multi-Tissue Omics Analysis Uncovers Translational Regulation Underlying Complex Traits in Pigs. [PDF]

Adv Sci (Weinh)
Wang C, Zhang Y, Chen C, Xu X, Qin S, Qi J, Bao Y, Li H, Chen R, Zheng W, Chen Z, Fang L, Zhao Y, Liu Y.   +13 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Identification of translationally deregulated proteins during inflammation-associated tumorigenesis

, 2012
The translation of mRNAs into proteins is an elaborate and highly regulated process. Translational regulation primarily takes place at the level of initiation.
Rübsamen, Daniela
core