Results 181 to 190 of about 617,976 (302)

Post-Translational Regulation of CD8⁺ T Cell Fate and Dysfunction in Tumor Immunity. [PDF]

Adv Sci (Weinh)
Zhou Z, Chen X, Li N, Zou M, Lin Y, Lin P, Feng W, Zhao X, Cui L.   +8 more
europepmc   +1 more source

The post-translational regulation of transcription factor EB (TFEB) in health and disease. [PDF]

EMBO Rep, 2023
Takla M, Keshri S, Rubinsztein DC.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Multimodal profiling reveals cell type-specific pseudouridine modification and density-dependent translational regulation. [PDF]

Nucleic Acids Res
McCormick CA, Meseonznik M, Qiu Y, Fanari O, Goyal P, Thomas M, Shokoufandeh M, Liu Y, Bloch D, Greenfield C, Klink IN, Jain M, Wanunu M, Rouhanifard SH.   +13 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Fragile histidine triad (FHIT) suppresses gastric cancer via translational regulation of the epigenetic modifier KDM6B. [PDF]

J Biol Chem
Hu H, Wang Y, Qi H, Liu G, Wang R, Shen J.   +5 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

TRMT6 mitigates susceptibility and progression of DSS-induced colitis multifacetedly via translational regulation. [PDF]

Sci Rep
Zhang X, Du Y, Ye Y, Zhong X, Cai C, Li G, Wang H, Wu A, Hong L.   +8 more
europepmc   +1 more source

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation. [PDF]

Cell Chem Biol, 2023
Muneer A, Wang L, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Jain K, Strahl BD, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X.   +19 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source