Results 21 to 30 of about 246,507 (257)
Translational medicine and the NIHR Biomedical Research Centre concept [PDF]
QJM, 2008 The realization of scientific discovery being delivered to patients for their clinical benefit is termed Translational Medicine. This requires the bridging of excellence in both basic scientific endeavour and clinical care. Whilst there is consensus that it is important to drive translation for the benefit of patient care, the mechanism whereby this is
Snape, K., Trembath, R. C., Lord, G. M.
openaire +3 more sources
SAHARA-J, 2018 New biomedical prevention technologies (NPTs) for HIV, including oral Pre-Exposure Prophylaxis, and vaginal and rectal microbicides and HIV vaccines in development, may contribute substantially to controlling the HIV epidemic.
Clara Rubincam +3 more
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Collaborative software for traditional and translational research
Human Genomics, 2012 Biomedical research has entered a period of renewed vigor with the introduction and rapid development of genomic technologies and next-generation sequencing methods.
Berman Ari E +2 more
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Translational Research and the Evolving Landscape for Biomedical Innovation [PDF]
Journal of Investigative Medicine, 2012 This article addresses current challenges facing pharmaceutical and biopharmaceutical developers, including the expiration of patents on many high-revenue–generating products, increasing competition in the marketplace, low public support, high regulatory hurdles, and the increasing time, cost, and risk of new product development.
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Using bibliometrics to evaluate outcomes and influence of translational biomedical research centers
Journal of Clinical and Translational Science, 2022 Introduction: Federal grant funding to support infrastructure development of translational biomedical research centers is a form of public health intervention.
Kristine M. Bragg +3 more
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Educación MédicaResumen: La medicina o investigación traslacional es una nueva rama de la medicina, que promueve el desarrollo científico a partir de la estrecha relación entre la investigación básica, preclínica y clínica, lo cual ha generado importantes avances en la ...
Manuel Latorre Quintana +2 more
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Translational Biomedical Informatics and Pharmacometrics Approaches in the Drug Interactions Research [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2018 Drug interaction is a leading cause of adverse drug events and a major obstacle for current clinical practice. Pharmacovigilance data mining, pharmacokinetic modeling, and text mining are computation and informatic tools on integrating drug interaction knowledge and generating drug interaction hypothesis.
Zhang, Pengyue +8 more
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MODERN APPROACHES TO THE ORGANIZATION OF TRANSLATIONAL RESEARCH
Педиатрическая фармакология, 2014 The growing distance between fundamental science and clinical medicine may bring risk of decreasing effectiveness of biomedical research. Translational research is a relatively new concept; it implies application of fundamental research results to ...
A. S. Kolbin +2 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source