Results 41 to 50 of about 50,720,175 (290)

Making translational value: Identifying ‘good targets’ for clinical research on gene editing and induced pluripotent stem cell technologies

SSM: Qualitative Research in Health, 2022
Biomedical translational researchers aim to develop knowledge and techniques arising from research in the life sciences into clinical applications. Using the examples of induced pluripotent stem cells (iPSC) and gene editing, this paper examines how ...
Michael Morrison, Andrew Bartlett
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Poor Translatability of Biomedical Research Using Animals — A Narrative Review

Alternatives to Laboratory Animals, 2023
The failure rate for the translation of drugs from animal testing to human treatments remains at over 92%, where it has been for the past few decades. The majority of these failures are due to unexpected toxicity — that is, safety issues revealed in human trials that were not apparent in animal tests — or lack of efficacy.
Lindsay J. Marshall, Jarrod Bailey, Manuela Cassotta, Kathrin Herrmann, Francesca Pistollato   +4 more
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Knowledge Production and Transfer in the Iranian Oral Health Research Centers: Based on Research Evaluation from 2019 to 2021

Frontiers in Dentistry
Due to the global burden of oral diseases, knowledge production and transfer are essential for clinical practice and policy. This descriptive study assessed 28 Iranian Oral Health Research Centers (OHRCs) from 13 medical universities (2019–2021), using ...
Katayoun Falahat, Monir Baradaran Eftekhari, Aboozar Ramezani   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The future of translational biomedical research at Nazarbayev University [PDF]

, 2014
The ultimate goal of fundamental biomedical research is to decipher mechanisms underlying the impairment of molecules, cells, tissues, and organs and subsequent dysfunction of the whole human body.
Alibek, K., Brusic, V., Saparov, A., Pignatelli, M.   +3 more
core   +1 more source

BATRACIO: BAsic, TRAnslational, Clinical, Research Phase Identification in BiOmedical Publications

IEEE Access
The increasing interest from research agencies, governments, and universities in understanding research funding and prioritising research efforts has highlighted the need for reliable and efficient methods for exploring research portfolios. In biomedical
Nicolau Duran-Silva, Jorge Carrillo-de-Albornoz, Laura Plaza, Sara Ricardo, Francesco A. Massucci, Sonia Veiga, Arnau Ramos-Prats   +6 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Echocardiography in translational research

, 2015
Departement Klinische Forschung, Forschungsgruppe Herz- und ...
Tevaearai, Hendrik, Monney, P, Jeanrenaud, X, Locca, D   +3 more
core   +1 more source