Results 51 to 60 of about 412,188 (300)

The Value of Comparative Animal Research : Krogh’s Principle Facilitates Scientific Discoveries [PDF]

, 2017
There are no conflicts of interest to declare. This paper developed from the 2016 Early Career Impact Award from the Federation of Associations in Behavioral & Brain Sciences to TJS. TJS has received funding from The Leverhulme Trust.
Alward, Beau A., Ebling, Francis J. P., Fernald, Russell D., Kelly, Aubrey, Ophir, Alexander G., Stevenson, Tyler J   +5 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Knowledge Production and Transfer in the Iranian Oral Health Research Centers: Based on Research Evaluation from 2019 to 2021

Frontiers in Dentistry
Due to the global burden of oral diseases, knowledge production and transfer are essential for clinical practice and policy. This descriptive study assessed 28 Iranian Oral Health Research Centers (OHRCs) from 13 medical universities (2019–2021), using ...
Katayoun Falahat, Monir Baradaran Eftekhari, Aboozar Ramezani   +2 more
doaj   +1 more source

Statistical competencies for medical research learners: What is fundamental? [PDF]

, 2017
IntroductionIt is increasingly essential for medical researchers to be literate in statistics, but the requisite degree of literacy is not the same for every statistical competency in translational research.
Benn, Emma KT, Carter, Rickey E, Enders, Felicity T, Grambow, Steven C, Kidwell, Kelley M, Larson, Joseph, Lindsell, Christopher J, Mayo, Matthew S, Oster, Robert A, Perkins, Susan M, Pollock, Brad H, Rahbar, Mohammad H, Spratt, Heidi, Thurston, Sally W, Welty, Leah J   +14 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Translational Biomedical Informatics and Pharmacometrics Approaches in the Drug Interactions Research [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2018
Drug interaction is a leading cause of adverse drug events and a major obstacle for current clinical practice. Pharmacovigilance data mining, pharmacokinetic modeling, and text mining are computation and informatic tools on integrating drug interaction knowledge and generating drug interaction hypothesis.
Zhang, Pengyue, Wu, Heng‐Yi, Chiang, Chien‐Wei, Wang, Lei, Binkheder, Samar, Wang, Xueying, Zeng, Donglin, Quinney, Sara K., Li, Lang   +8 more
openaire   +2 more sources

BATRACIO: BAsic, TRAnslational, Clinical, Research Phase Identification in BiOmedical Publications

IEEE Access
The increasing interest from research agencies, governments, and universities in understanding research funding and prioritising research efforts has highlighted the need for reliable and efficient methods for exploring research portfolios. In biomedical
Nicolau Duran-Silva, Jorge Carrillo-de-Albornoz, Laura Plaza, Sara Ricardo, Francesco A. Massucci, Sonia Veiga, Arnau Ramos-Prats   +6 more
doaj   +1 more source

Towards Automatic Extraction of Social Networks of Organizations in PubMed Abstracts

, 2010
Social Network Analysis (SNA) of organizations can attract great interest from government agencies and scientists for its ability to boost translational research and accelerate the process of converting research to care.
Gonzalez, Graciela, Jonnalagadda, Siddhartha, Topham, Philip   +2 more
core   +1 more source

Noninvasive depth estimation using tissue optical properties and a dual-wavelength fluorescent molecular probe in vivo [PDF]

, 2017
Translation of fluorescence imaging using molecularly targeted imaging agents for real-time assessment of surgical margins in the operating room requires a fast and reliable method to predict tumor depth from planar optical imaging.
Achilefu, Samuel, Lam, Jesse, Maji, Dolonchampa, Miller, Jessica P, Tromberg, Bruce J   +4 more
core   +2 more sources