Results 51 to 60 of about 50,720,175 (290)

Translating innovation in biomedical research: Design and delivery of a competency-based regulatory science course

Journal of Clinical and Translational Science, 2020
As the pace of biomedical innovation rapidly evolves, there is a need to train researchers to understand regulatory science challenges associated with clinical translation.
Alexandra J. Greenberg-Worisek, Katherine E. Cornelius, Luz Cumba Garcia, Felicity T. Enders, Nilay D. Shah, Anthony J. Windebank   +5 more
doaj   +1 more source

Translational Cancer Nursing Research: What will your contribution be?

, 2016
Over the past decade, reference to translational research has increasingly dominated our research semantic. There are multiple definitions of translational research, but the most commonly understood is the transfer of biomedical knowledge from bench to ...
Krishnasamy, Meinir, Chan, Raymond J, Chan, Raymond J., Krishnasamy, Mei   +3 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Mapping the evolving definitions of translational research

Journal of Clinical and Translational Science, 2017
Objective Systematic review and analysis of definitions of translational research. Materials and methods The final corpus was comprised of 33 papers, each
Daniel G. Fort, Timothy M. Herr, Pamela L. Shaw, Karen E. Gutzman, Justin B. Starren   +4 more
doaj   +1 more source

Translational research combining orthologous genes and human diseases with the OGOLOD dataset [PDF]

, 2012
OGOLOD is a Linked Open Data dataset derived from different biomedical resources by an automated pipeline, using a tailored ontology as a scaffold.
Egaña Aranguren, Mikel, Miñarro-Giménez, José Antonio, Fernández-Breis, Jesualdo Tomás, Villazón-Terrazas, Boris   +3 more
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

PubMed-Scale Event Extraction for Post-Translational Modifications, Epigenetics and Protein Structural Relations [PDF]

, 2012
Recent efforts in biomolecular event extraction have mainly focused on core event types involving genes and proteins, such as gene expression, protein-protein interactions, and protein catabolism.
Björne, Jari, Ginter, F, Van de Peer, Yves, Ohta, T, Ohta, Tomoko, Van Landeghem, S, Van Landeghem, Sofie, Pyysalo, S, Ananiadou, S; id_orcid, Van de Peer, Y, Ananiadou, Sophia, Salakoski, Tapio, Björne, J, Ginter, Filip, Salakoski, T, Pyysalo, Sampo   +15 more
core  

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source