Results 71 to 80 of about 412,188 (300)

Progress toward a universal biomedical data translator

Clinical and Translational Science, 2022
Clinical, biomedical, and translational science has reached an inflection point in the breadth and diversity of available data and the potential impact of such data to improve human health and well‐being. However, the data are often siloed, disorganized,
Karamarie Fecho, Anne E. Thessen, Sergio E. Baranzini, Chris Bizon, Jennifer J. Hadlock, Sui Huang, Ryan T. Roper, Noel Southall, Casey Ta, Paul B. Watkins, Mark D. Williams, Hao Xu, William Byrd, Vlado Dančík, Marc P. Duby, Michel Dumontier, Gustavo Glusman, Nomi L. Harris, Eugene W. Hinderer, Greg Hyde, Adam Johs, Andrew I. Su, Guangrong Qin, Qian Zhu, The Biomedical Data Translator Consortium   +24 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Infectious Disease Ontology [PDF]

, 2009
Technological developments have resulted in tremendous increases in the volume and diversity of the data and information that must be processed in the course of biomedical and clinical research and practice.
A Bresell, A Djebbari, A Doms, A Ruttenberg, A Valouev, AC Yu, B Grinde, B Smith, B Smith, B Smith, B Smith, B Zhang, BR Zeeberg, C Medigue, C Rosse, C Schonbach, C Wolting, CA Schurink, CH Kim, D Huang, D Pisanelli, DA Natale, DL Buckeridge, DL Buckeridge, DL Rubin, DL Rubin, DP Hill, E Camon, F Baader, G Grumbling, H Tveit, HM Muller, I Spasic, J Bard, J Chabalier, J Kohler, JA Blake, JA Lee, JD Osborne, JM Cherry, K Thursky, KL Rickard, KM Coonan, LT Detwiler, M Brameier, M Coleman, M Rajapakse, MF Ochs, N Guarino, N Tiffin, NC Ide, O Bodenreider, O Bodenreider, PL Whetzel, R Cornet, SA Racunas, SE Baranzini, SL Pestotnik, TG Veenema, V Sintchenko, W Ceusters, W Ceusters, W Ceusters   +62 more
core   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Implications of observation-fact modifiers to i2b2 ontologies [PDF]

, 2011
Biomedical translational research can be facilitated by integrating clinical and research data. In particular, study cohort identification and hypothesis generation is enabled by the mining of integrated clinical observations and research resources. The
Chatterjee, Devjani, London, Jack W.
core   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Preventing Translational Scientists From Extinction: The Long-Term Impact of a Personalized Training Program in Translational Medicine on the Careers of Translational Scientists

Frontiers in Medicine, 2018
Far too much biomedical research is wasted and ends in the so called “Valley of Death”: the gap that exists between biomedical research and its clinical application. While the translational process requires collaboration between many disciplines, current
Margot M. Weggemans, Marieke van der Schaaf, Manon Kluijtmans, Manon Kluijtmans, Janet P. Hafler, Janet P. Hafler, Norman D. Rosenblum, Norman D. Rosenblum, Berent J. Prakken, Berent J. Prakken   +9 more
doaj   +1 more source

Translational research combining orthologous genes and human diseases with the OGOLOD dataset

, 2012
OGOLOD is a Linked Open Data dataset derived from different biomedical resources by an automated pipeline, using a tailored ontology as a scaffold.
Egaña Aranguren, Mikel, Fernández-Breis, Jesualdo Tomás, Miñarro-Giménez, José Antonio, Villazón-Terrazas, Boris   +3 more
core  

Plasma REST: a novel candidate biomarker of Alzheimer's disease is modified by psychological intervention in an at-risk population. [PDF]

, 2017
The repressor element 1-silencing transcription (REST) factor is a key regulator of the aging brain's stress response. It is reduced in conditions of stress and Alzheimer's disease (AD), which suggests that increasing REST may be neuroprotective.
Ashton, NJ, Elliott, C, Gardner, A, Hye, A, Jones, AR, Killick, R, Leckey, CA, Lenze, EJ, Marchant, NL, Wetherell, JL   +9 more
core   +3 more sources