Results 61 to 70 of about 412,188 (300)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Science, innovation and technology transfer pathways in translational research: a study of divergent trajectories in the healthcare sector in Europe [PDF]
, 2016 The geography of the biomedical sector, that of clustering in particular regions, presents an opportunity for place-specific understanding of processes involved in translational research in medical sciences, particularly with regard to the role of public
Bagchi-Sen, S. +2 more
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Mapping the evolving definitions of translational research
Journal of Clinical and Translational Science, 2017 Objective Systematic review and analysis of definitions of translational research. Materials and methods The final corpus was comprised of 33 papers, each
Daniel G. Fort +4 more
doaj +1 more source
The miniature pig: as an experimental model fordental and orofacial research
生物医学转化, 2021 Because its anatomical morphology, physiological structure and pathological mechanism of the oral and maxillofacial systems are more similar to human, miniature pig has significant advantages as a model animal for oral and maxillofacial biomedical ...
Zhou Jian, Yang Zi, Wang Songlin
doaj +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Translational Research and the Evolving Landscape for Biomedical Innovation [PDF]
Journal of Investigative Medicine, 2012 This article addresses current challenges facing pharmaceutical and biopharmaceutical developers, including the expiration of patents on many high-revenue–generating products, increasing competition in the marketplace, low public support, high regulatory hurdles, and the increasing time, cost, and risk of new product development.
openaire +2 more sources
Journal of Clinical and Translational Science, 2020 As the pace of biomedical innovation rapidly evolves, there is a need to train researchers to understand regulatory science challenges associated with clinical translation.
Alexandra J. Greenberg-Worisek +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
42 Why is the concept of translational science so hard to define and apply?
Journal of Clinical and Translational ScienceObjectives/Goals: In CTSA funding calls issued since 2021, the NCATS has differentiated the terms “translational research” and “translational science” which has resulted in confusion between the terms.
Elise Smith +3 more
doaj +1 more source