Results 61 to 70 of about 50,720,175 (290)

Progress toward a universal biomedical data translator

Clinical and Translational Science, 2022
Clinical, biomedical, and translational science has reached an inflection point in the breadth and diversity of available data and the potential impact of such data to improve human health and well‐being. However, the data are often siloed, disorganized,
Karamarie Fecho, Anne E. Thessen, Sergio E. Baranzini, Chris Bizon, Jennifer J. Hadlock, Sui Huang, Ryan T. Roper, Noel Southall, Casey Ta, Paul B. Watkins, Mark D. Williams, Hao Xu, William Byrd, Vlado Dančík, Marc P. Duby, Michel Dumontier, Gustavo Glusman, Nomi L. Harris, Eugene W. Hinderer, Greg Hyde, Adam Johs, Andrew I. Su, Guangrong Qin, Qian Zhu, The Biomedical Data Translator Consortium   +24 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

The importance of basic and translational research in caring for children with malignant solid tumors in Latin America

Revista Panamericana de Salud Pública
Objective. Basic and translational research in pediatric cancer are essential to improve patient care. To critically assess the developments achieved in these areas in Latin America, we systematically reviewed information published between 2013 and 2023.
María Belen Cancela, Milagros Dinardi, Rosario Aschero, Santiago Zugbi, Guillermo Chantada, Lorena Baroni, Paula Schaiquevich   +6 more
doaj   +1 more source

Preventing Translational Scientists From Extinction: The Long-Term Impact of a Personalized Training Program in Translational Medicine on the Careers of Translational Scientists

Frontiers in Medicine, 2018
Far too much biomedical research is wasted and ends in the so called “Valley of Death”: the gap that exists between biomedical research and its clinical application. While the translational process requires collaboration between many disciplines, current
Margot M. Weggemans, Marieke van der Schaaf, Manon Kluijtmans, Manon Kluijtmans, Janet P. Hafler, Janet P. Hafler, Norman D. Rosenblum, Norman D. Rosenblum, Berent J. Prakken, Berent J. Prakken   +9 more
doaj   +1 more source

Translational Research Part 2

, 2017
Week 2: Translational Research and Big Data 2.2 Translational Research Translational Research Lecture Part 2Demystifying Biomedical Big Data BIOX-201 ...
Haddad, Bassem, Gusev, Yuriy, McGarvey, Peter   +2 more
core  

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Recent advances in theranostic nanomaterials for overcoming traumatic brain injury

Journal of Nanobiotechnology
Traumatic brain injury (TBI) is a major global health challenge characterized by complex secondary injury mechanisms involving oxidative stress, inflammation, and blood-brain barrier (BBB) disruption.
Nam Cheol Hwang, Dong Min Lim, Tae Sik Goh, Jung Mo Kang, Jaehoon Kim, Shin Kim, Yun Hak Kim, Dokyoung Kim   +7 more
doaj   +1 more source

Proteomics in Biomedical Research and Translational Medicine [PDF]

, 2022
A significant proportion of basic proteomic research is directed towards the clinic, largely aimed at the identification of proteins as potential biomarkers of pathological conditions. Reliable protein profiling is of particular importance in the field of plasma biomarker research where selected proteins must be consistently identified and quantified ...
openaire