Results 71 to 80 of about 404,871 (284)

A translational framework for public health research [PDF]

, 2009
<p><b>Background</b></p> <p>The paradigm of translational medicine that underpins frameworks such as the Cooksey report on the funding of health research does not adequately reflect the complex reality of the public health ...
A Bradford Hill, A Lyon, A Raffle, A Wakefield, B Lo, Committee of Inquiry into the Future Development of the Public Health Function, D Cooksey, D Dougherty, D Elliman, D Ogilvie, D Ogilvie, D Wanless, David Ogilvie, E Ginexi, F Cappuccio, Foresight, G Duyk, I Chalmers, J Lavis, J Lavis, J Lavis, J Tudor Hart, J Westfall, K Narayan, K Narayan, L Arai, L Bero, M Lean, M Petticrew, M Petticrew, M Petticrew, M Petticrew, M Whitehead, N Cook, N Saeed, N Sung, Nicholas J Wareham, P Alderson, P Blair, P Craig, P Craig, P Wilson, Peter Craig, R Beaglehole, R Gilbert, R Horton, R Pawson, S Cummins, S Hanney, S Hilton, S Innvær, S Kuruvilla, S Sussman, S Woolf, Sally Macintyre, Simon Griffin, T Greenhalgh, T Sheldon   +57 more
core   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Progress toward a universal biomedical data translator

Clinical and Translational Science, 2022
Clinical, biomedical, and translational science has reached an inflection point in the breadth and diversity of available data and the potential impact of such data to improve human health and well‐being. However, the data are often siloed, disorganized,
Karamarie Fecho, Anne E. Thessen, Sergio E. Baranzini, Chris Bizon, Jennifer J. Hadlock, Sui Huang, Ryan T. Roper, Noel Southall, Casey Ta, Paul B. Watkins, Mark D. Williams, Hao Xu, William Byrd, Vlado Dančík, Marc P. Duby, Michel Dumontier, Gustavo Glusman, Nomi L. Harris, Eugene W. Hinderer, Greg Hyde, Adam Johs, Andrew I. Su, Guangrong Qin, Qian Zhu, The Biomedical Data Translator Consortium   +24 more
doaj   +1 more source

Towards an alternative framework for the evaluation of translational research initiatives [PDF]

, 2014
Ingenio Working Paper SeriesThis paper will propose a framework for evaluating translational research by identifying the way in which translational research occurs in practice (rather than the formal linear stages in which the results of such process are
D'Este Cukierman, Pablo, Llopis Córcoles, Óscar, Molas Gallart, Jordi, Rafols, Ismael   +3 more
core  

An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]

, 2015
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro, Onwuli, Donatus O.   +1 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

3339 Development of a Competency-based Informatics Course for Translational Researchers

Journal of Clinical and Translational Science, 2019
OBJECTIVES/SPECIFIC AIMS: Translational researchers often require the use of informatics methods in their work. Lack of an understanding of key informatics principles and methods limits the abilities of translational researchers to successfully implement
Ram Gouripeddi, Danielle Groat, Samir E. Abdelrahman, Tom Cheatham, Mollie Cummins, Karen Eilbeck, Bernie LaSalle, Katherine Sward, Julio C. Facelli   +8 more
doaj   +1 more source

Collective intelligence for translational medicine: Crowdsourcing insights and innovation from an interdisciplinary biomedical research community. [PDF]

, 2015
This is the author accepted manuscript. The final version is available from Taylor & Francis via http://dx.doi.org/10.3109/07853890.2015.1091945Translational medicine bridges the gap between discoveries in biomedical science and their safe and effective ...
Budge, Eleanor Jane, Howgate, Daniel James, Jalali, Morteza, Sivakumar, Shivan, Tsoti, Sandra Maria   +4 more
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Toll-Like Receptor 8 Agonist and Bacteria Trigger Potent Activation of Innate Immune Cells in Human Liver [PDF]

, 2014
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The study was ...
A Fosdick, A Schurich, Adam J. Gehring, Adeline Chia, AL Blasius, Alfonso Tan-Garcia, Anthony T. Tan, Antonio Bertoletti, AT Tan, Christian B. Willberg, Christopher M. Walker, D Peppa, DB Tumas, DT Lau, E Liaskou, E Raz, E Treiner, Elena Sandalova, F Heil, FV Chisari, Gennaro De Libero, IN Crispe, J Cros, J Lee, James E. Ussher, JE Ussher, JL Cervantes, JM Schenkel, Juandy Jo, K Kakimi, K Kariko, K Kimura, Kai Chah Tan, Kang Hoe Lee, L Kjer-Nielsen, L Le Bourhis, LE Sander, LG Guidotti, LG Guidotti, Michelle Hong, MP Gantier, Natalie To, P Lan, Patrick T. Kennedy, Paul Klenerman, RE Lanford, SS Diebold, U Protzer, Upkar S. Gill, VJ Cavanaugh, WJ Chua, WY Lee, Xin-Zi Tang, XZ Tang, Y Horsmans, Z Tu   +55 more
core   +3 more sources