Results 81 to 90 of about 404,871 (284)

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Exploring the potential of computer simulation models in drug testing and biomedical research: a systematic review

Frontiers in Pharmacology
IntroductionThe growing limitations of animal models in drug testing and biomedical research, including ethical concerns, high costs, and poor translational relevance to human biology, have driven increasing interest in computational simulation models ...
Rahul Mittal, Rahul Mittal, Alan Ho, Harini Adivikolanu, Muskaan Sawhney, Joana R. N. Lemos, Joana R. N. Lemos, Mannat Mittal, Khemraj Hirani, Khemraj Hirani   +9 more
doaj   +1 more source

Building diverse careers in clinical and translational research: Evaluation of a certificate program in translational research

Journal of Clinical and Translational Science, 2018
IntroductionThe Certificate Program in Translational Research (CPTR) at the Georgia Clinical and Translational Science Alliance provides Ph.D. students, postdoctoral fellows and faculty with didactic, mentored, and experiential training in clinical and ...
Dawn L. Comeau, Jessica A. Alvarez, Pamela Bhatti, Douglas F. Paulsen, Alexander Quarshie, Cam Escoffery, Igho Ofotukun, Hannah Eisen, Thomas R. Ziegler, Henry M. Blumberg   +9 more
doaj   +1 more source

Translational research combining orthologous genes and human diseases with the OGOLOD dataset

, 2012
OGOLOD is a Linked Open Data dataset derived from different biomedical resources by an automated pipeline, using a tailored ontology as a scaffold.
Egaña Aranguren, Mikel, Fernández-Breis, Jesualdo Tomás, Miñarro-Giménez, José Antonio, Villazón-Terrazas, Boris   +3 more
core  

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

The importance of basic and translational research in caring for children with malignant solid tumors in Latin America

Revista Panamericana de Salud Pública
Objective. Basic and translational research in pediatric cancer are essential to improve patient care. To critically assess the developments achieved in these areas in Latin America, we systematically reviewed information published between 2013 and 2023.
María Belen Cancela, Milagros Dinardi, Rosario Aschero, Santiago Zugbi, Guillermo Chantada, Lorena Baroni, Paula Schaiquevich   +6 more
doaj   +1 more source

Bimetra Biobank: A High Quality Biobank Facility to Stimulate Translational Biomedical Research

Open Journal of Bioresources, 2018
Bimetra Biobank is the central high quality biorepository of University Hospital Ghent in collaboration with Ghent University (Belgium). Fully operational since 2015 in a new state-of-the-art biobank facility, Bimetra Biobank acts as a core facility for ...
Veronique T'Joen, Sara Phlypo, Sofie Bekaert   +2 more
doaj   +1 more source

Developing the Quantitative Histopathology Image Ontology : A case study using the hot spot detection problem [PDF]

, 2017
Interoperability across data sets is a key challenge for quantitative histopathological imaging. There is a need for an ontology that can support effective merging of pathological image data with associated clinical and demographic data.
Doyle, Scott, Gurcan, Metin, James, A., John, Overton, N., Tomaszewski, Ruttenberg, Alan, Smith, Barry   +6 more
core  

Depression and suicide risk prediction models using blood-derived multi-omics data [PDF]

, 2019
More than 300 million people worldwide experience depression; annually, ~800,000 people die by suicide. Unfortunately, conventional interview-based diagnosis is insufficient to accurately predict a psychiatric status. We developed machine learning models
Bhak, Jong, Bhak, Youngjune, Blazyte, Asta, Cho, Juok, Cho, Yun Sung, Gim, Jeong-An, Ham, Byung-Joo, Jeon, Sungwon, Jeon, Yeonsu, Jeong, Hyoung-oh, Kang, Wooyoung, Kim, Aram, Kim, Byung Chul, Kim, Hak-Min, Kim, Yumi, Lee, Hae-Woo, Lee, Semin, Paik, Jong-Woo, Park, Seung Gu, Shin, Eun-Seok   +19 more
core   +1 more source

Proteomics in Biomedical Research and Translational Medicine [PDF]

, 2022
A significant proportion of basic proteomic research is directed towards the clinic, largely aimed at the identification of proteins as potential biomarkers of pathological conditions. Reliable protein profiling is of particular importance in the field of plasma biomarker research where selected proteins must be consistently identified and quantified ...
openaire